Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain • Hacker News Board

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#51

Post by xkcd-sucks » Thu, Sep 07, 2017, 10:23 PM UTC

lightedman wrote: post #27

kinleyd wrote: post #10

Hmm, seems like it's time to seriously consider extracting some THC and CBD. I'm looking at this: https://magicalbutter.com/ . Anyone have some experience with this type of gear?

Butter is okay but I highly recommend just making an extract you can vaporize. Most people don't realize that Delta-9-THC turns even more psychoactive when it undergoes a liver pass, converting into another delta analogue of the molecule. Pure acetone (no colorants or scents added) and a hot plate is all you need. Acetone wash your ground material for 10 seconds, filter/strain through coffee filters onto a hot plate…

One problem with acetone is it's pretty hygroscopic, so it will absorb water from the atmosphere or any plant material that's not bone dry. Then you're left with water in the extract when the acetone is boiled off. Alcohols are worse as they form azeotropes with water. Also the more polar things (basically anything other than -ane) tend to extract sugars, pigments, etc.

Saturated unsubstituted hydrocarbons (e.g. hexane) are really nice to work with, e.g. provide similar results to butane at room temperature/pressure. Heptane is nice because it can in principle be "natural" if sourced from Jeffrey pine oil, but I haven't seen that for sale...

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#52

Post by icanhackit » Thu, Sep 07, 2017, 11:21 PM UTC

Danihan wrote: post #30

JamesBarney wrote: post #28

Earlier quoted context omitted.

Yeah over the past few years I've been convinced that beta amyloid is a not a cause of Alzheimer's but a red herring symptom. Too many drugs have failed. Maybe its a disease caused by glial cell dysfunction where beta amyloid is just the most obvious but not most important piece of trash that collects in the brain. And it's just a terrible coincidence injections of beta amyloid have similar effects as Alzheimer's.

IMO it's neuronal autophagy failing. Plaques accumulating and PH being thrown off are symptoms of that.

Based on your hunch do you think the FOX04 peptide, which in mice showed promising results in destroying senescent cells and reducing arterial plaques, might be a solution?

https://en.wikipedia.org/wiki/FOXO4

http://www.sciencemag.org/news/2017/03/molecule-kills-elderl...

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#53

Post by lightedman » Fri, Sep 08, 2017, 1:12 AM UTC

xkcd-sucks wrote: post #51

lightedman wrote: post #27

Earlier quoted context omitted.

Butter is okay but I highly recommend just making an extract you can vaporize. Most people don't realize that Delta-9-THC turns even more psychoactive when it undergoes a liver pass, converting into another delta analogue of the molecule. Pure acetone (no colorants or scents added) and a hot plate is all you need. Acetone wash your ground material for 10 seconds, filter/strain through coffee filters onto a hot plate…

One problem with acetone is it's pretty hygroscopic, so it will absorb water from the atmosphere or any plant material that's not bone dry. Then you're left with water in the extract when the acetone is boiled off. Alcohols are worse as they form azeotropes with water. Also the more polar things (basically anything other than -ane) tend to extract sugars, pigments, etc. Saturated unsubstituted hydrocarbons (e.g. hexa…

"Then you're left with water in the extract when the acetone is boiled off."

This is why you've got it on the hot plate for an hour - at 150F the acetone's gone in 20 minutes, you need the other 40 minutes to purge the water from the extract.

Heptane is also about 6x the price of acetone.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#54

Post by kinleyd » Fri, Sep 08, 2017, 5:12 AM UTC

ineptech wrote: post #48

kinleyd wrote: post #36

Earlier quoted context omitted.

Thank you. Yes, it is figuring out the dosing that concerns me.

To reiterate what someone else has already said, vaporizing is indisputably the way to go. When vaporizing, you can use a bit, wait 5-10 minutes, and then decide whether to use more. With edibles you don't know if you got the dosage right or not for 60+ minutes.

Thanks. This point does stand out as an important takeaway from all that I've read here.