Having lived in Indianapolis for about 15 years, I also say it is unlikely. The talent pool is too shallow, because tech employers just haven't
been there. I had to move to Chicago after graduating in order to get a [decent, career-advancing] job as a software professional. The majority of my high school friends also moved out to find jobs after college.
And parent confirms some of the other problems I have with Indy. Unigov overwhelmed the urban core with township voters, so city-county government is atypically conservative for a Midwestern city, which has a major impact on statewide politics. (Still less conservative than where I am now, though, and trust me when I say that being liberal or libertarian in a conservative state is like rubbing a cheese grater on your soul every time you visit the polls--no good options, and sometimes you don't even get two whole evils from which to choose the lesser.)
If you want to fly anywhere, you have to connect through ORD (American, United), MDW (Southwest), or ATL (Delta, Southwest). The direct flight to anywhere probably only runs once a day or less.
Also, all the tech people with kids will undoubtedly cluster in southern Hamilton county, and Washington or Lawrence townships, which won't be great for traffic, because there's no limited-access highway to downtown from anywhere on the north side. And what public transit? I might have seen a bus once or twice, while visiting downtown, within a 5-block radius of the circle. And the hospitals have a monorail since the merger, I guess. Beyond that, you're driving or walking.