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Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

futurism.com

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Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#11

Post by jackhack »

chillingeffect wrote: post #3

article is a value-added summary of: https://www.sciencedaily.com/releases/2016/06/160629095609.h... which is based on this press release: http://www.salk.edu/news-release/cannabinoids-remove-plaque-... original paper here: https://www.nature.com/articles/npjamd201612 "Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids" original paper: https://www.nature.com/articles/npjamd201612.pdf

Thank you for linking to real science. The fluff-piece is almost unbearable. Poor editing and foolish attempts at humor. Science for dummies.

"But THC can also bind to them in much the same way, and when they do, they start messing with your brain’s ability to communicate with itself. The [SIC] can be a good and a bad thing, because while you might forget something important or suddenly be incapable of swinging a baseball bat, you’ll probably feel amazing, and want to eat all the snacks:"

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#12

Post by ianai »

kinleyd wrote: post #10

Hmm, seems like it's time to seriously consider extracting some THC and CBD. I'm looking at this: https://magicalbutter.com/ . Anyone have some experience with this type of gear?

An older relative of mine uses a machine like that. He uses the butter to bake edibles for his dad. It's really helped with neuropathy and pain management.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#13

Post by kinleyd »

ianai wrote: post #12
kinleyd wrote: post #10

Hmm, seems like it's time to seriously consider extracting some THC and CBD. I'm looking at this: https://magicalbutter.com/ . Anyone have some experience with this type of gear?

An older relative of mine uses a machine like that. He uses the butter to bake edibles for his dad. It's really helped with neuropathy and pain management.

Thank you. I think I will give it a try as well. We are running out of options for my father - perhaps this would be a good Hail Mary.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#14

Post by hprotagonist »

kinleyd wrote: post #10

Hmm, seems like it's time to seriously consider extracting some THC and CBD. I'm looking at this: https://magicalbutter.com/ . Anyone have some experience with this type of gear?

if you happen to have a moka pot around it's the same idea. lower heat, load the bottom with a fat, and decarboxylate the herb first.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#15

Post by jjuel »

ianai wrote: post #7
jjuel wrote: post #5

The problem is this will never get funded or passed due to the Big Pharma lobbyists.

All that really needs to happen is federal legalization. Once that's done, it doesn't matter whether pharma is behind it or not. I bet though they would quickly release all sorts of cannabinoid products. (Not everyone wants to be high/timed release doses etc)

That is basically what I meant though. I don't see it being an easy sell to get federal legalization.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#16

Post by ianai »

jjuel wrote: post #15
ianai wrote: post #7

Earlier quoted context omitted.

All that really needs to happen is federal legalization. Once that's done, it doesn't matter whether pharma is behind it or not. I bet though they would quickly release all sorts of cannabinoid products. (Not everyone wants to be high/timed release doses etc)

That is basically what I meant though. I don't see it being an easy sell to get federal legalization.

It seems like there should be enough lobby money there. Both tobacco companies and pharma companies could benefit from it.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#17

Post by ianai »

kinleyd wrote: post #13
ianai wrote: post #12

Earlier quoted context omitted.

An older relative of mine uses a machine like that. He uses the butter to bake edibles for his dad. It's really helped with neuropathy and pain management.

Thank you. I think I will give it a try as well. We are running out of options for my father - perhaps this would be a good Hail Mary.

Just do your research on dosing and what your father will tolerate. It may be more beneficial to get one of the strands that gives no high. Good luck , I'm sure it's not easy.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#18

Post by kortex »

jjuel wrote: post #5

The problem is this will never get funded or passed due to the Big Pharma lobbyists.

Tired old argument. Just because X natural product (eg THC) is not patentable does not mean that you can't just come up with analog Y with similar activity, and patent that. Taxol for example.

Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain

#20

Post by guyt00 »

Problems with this terrible title:

1. In vitro petri dish testing is a million light years away from showing a compound works in humans.

2. This is a particularly bad problem in brain diseases as getting your compound to cross the blood-brain barrier in correct therapeutic quantities is extremely difficult.

3. We have lots of direct antibodies that kill beta amyloid in vivo that are very advanced in human trials. The problem now is that they often cause micro-damage when removing various forms of amyloid protein or have been shown to be administered far too late when the damage is already done.

4. It's still not clear that beta amyloid is even the main causal agent of Alzheimers!

In general, if you see someone touting a low effort, pre-clinical study as major medical breakthrough, start hitting the downvote button. I'm disappointed this even got to the main page.

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