Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
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Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#2A very exciting petri dish result! If this actually works in an animal model, it could be a true breakthrough. I am wondering if THC in vivo might undergo some kind of subtle metabolism after being ingested or smoked so that it still binds to cannaboid receptors, but doesn't affect beta amyloid.
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#3article is a value-added summary of:
https://www.sciencedaily.com/releases/2016/06/160629095609.h...
which is based on this press release: http://www.salk.edu/news-release/cannabinoids-remove-plaque-...
original paper here: https://www.nature.com/articles/npjamd201612 "Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids"
original paper: https://www.nature.com/articles/npjamd201612.pdf
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#4wow.. who would have ever thought that MJ would be good for memory..
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#5The problem is this will never get funded or passed due to the Big Pharma lobbyists.
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#6A very exciting petri dish result! If this actually works in an animal model, it could be a true breakthrough. I am wondering if THC in vivo might undergo some kind of subtle metabolism after being ingested or smoked so that it still binds to cannaboid receptors, but doesn't affect beta amyloid.
I skimmed the article. I'm way out of my comfort zone here, but I think they covered that. I think they said cannabinoids are converted to something lose that stops the progression to cell death.
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#7The problem is this will never get funded or passed due to the Big Pharma lobbyists.
All that really needs to happen is federal legalization. Once that's done, it doesn't matter whether pharma is behind it or not. I bet though they would quickly release all sorts of cannabinoid products. (Not everyone wants to be high/timed release doses etc)
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#8A very exciting petri dish result! If this actually works in an animal model, it could be a true breakthrough. I am wondering if THC in vivo might undergo some kind of subtle metabolism after being ingested or smoked so that it still binds to cannaboid receptors, but doesn't affect beta amyloid.
If I recall correctly (from a radiolab interview w/ Dr.Tsai [0]), something like 99% of animal model successes don't transfer to humans.
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#9article is a value-added summary of: https://www.sciencedaily.com/releases/2016/06/160629095609.h... which is based on this press release: http://www.salk.edu/news-release/cannabinoids-remove-plaque-... original paper here: https://www.nature.com/articles/npjamd201612 "Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids" original paper: https://www.nature.com/articles/npjamd201612.pdf
thank you! This type of work is super valuable
Re: Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain
#10Hmm, seems like it's time to seriously consider extracting some THC and CBD. I'm looking at this: https://magicalbutter.com/. Anyone have some experience with this type of gear?