>The surface contact of perfect cylinder (a regular car tire), and a perfect sphere (the iTire) is the same: 0 cm^2.
A perfect cylinder has a line of contact with the road: the width of the wheel. A perfect sphere has a point of contact.
Obviously you wouldn't see perfect eithers when talking about real-world tire implementations, but the perfect examples here are indicative of cylinders having more surface area with higher air pressure, whereas higher air pressure is the preferred state due to wheel wear and tear and handling issues that occur at low pressures.
Not to mention cylindrical wheels inherently resist lateral motion, have lower unsprung weights/volumes, and don't have the unnecessary engineering struggles of turning a spherical object into a pneumatic device.
I'm all for trying new things and testing wacky designs, but lots of people have looked at spherical wheels over the past few decades (Goodyear's implementation is a personal favorite[1]) and concluded they're pretty much just good looking, rather than an improvement in engineering over current wheels.
Given how good they look though, I'd love for someone to find a way to make them actually work.
[1] https://www.youtube.com/watch?v=oSFYwDDVgac