I remember a talk by a NASA guy that a first try would be to land some people with limited supplies on the Antarctic and let them live autonomously for a few years. He said before we go to Mars we need the ability to do this easily.
Or try an other biosphere experiment[1]. The problem is, it would cost almost as much as a real mars mission. So it's not sure it'd be worth it. 1. https://en.wikipedia.org/wiki/Biosphere_2
If the first one fails, how likely are we to continue doing it, considering the present challenges we face on Earth?