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Peanut allergy cured in majority of children in immunotherapy trial

theguardian.com

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Re: Peanut allergy cured in majority of children in immunotherapy trial

#61
post #35
post #13

Earlier quoted context omitted.

You'd have to convince me that lobster is a Veblen good. Yes, it's often priced as a luxury good once you get away from the New England coast--and sometimes even there--but that's not the same thing as saying higher prices increase demand. I expect the restaurant selling $25 lobster rolls would sell more if they were a more reasonable $12 but they might not make as much money. I do like lobster when the price is reas…

We used to use Lobster as prison food / dog food because nobody liked it. It's mostly a tasteless meat which has become more popular as westerners have shifted to blander foods. http://www.npr.org/sections/thesalt/2015/03/26/394339284/how...

It holds butter real well, without it soaking in too much.

Re: Peanut allergy cured in majority of children in immunotherapy trial

#62
post #39

My daughter has Celiac disease. It was diagnosed at age 4 when her growth chart showed she did not gain a single pound and grew ¼" from age 3-4. We did a biopsy of her small intestine and it was completely smooth. (Should be almost like velvet) Herblood levels also showed high sensitivity to gluten. We have her on a strict gluten free diet and she has since followed the growth chart perfectly. However she is sensitiv…

Sorry to hear that - but I understand that Celiac disease it not an immune response in the same manner - so likely any treatment will be different to this - though as ever - probiotics and gut bacteria are worth a try. My wife has celiac disease too, and I really wouldn't worry too much - it is pretty damn easy to eat out now (in the UK, Europe and America at least) - and compared to 10 years ago, she can shop really simply and have high confidence when eating out. We've traveled widely, and it's not been an issue either - as long as you take notes in the language of the country you are going to: http://www.celiactravel.com/cards/

Plus - as horrible as a reaction is nothing compared to an allergic/anaphylactic response from ingesting a known allergen.

Re: Peanut allergy cured in majority of children in immunotherapy trial

#63

I'm a parent of a 4-year old with a peanut allergy. We've been told that anywhere from 18-25% of kids with it "outgrow" the allergy by age 5. I've been looking into private practice oral immunotherapy (OIT) recently, which this protocol seems to be a variant of (adding the bacteria). My understanding is that you start with a low dose and then gradually increase over months until you're eating whole peanuts (4-12 of t…

It is a great time for this study - really hopeful for my child too :)

Re: Peanut allergy cured in majority of children in immunotherapy trial

#64

I'm a parent of a 4-year old with a peanut allergy. We've been told that anywhere from 18-25% of kids with it "outgrow" the allergy by age 5. I've been looking into private practice oral immunotherapy (OIT) recently, which this protocol seems to be a variant of (adding the bacteria). My understanding is that you start with a low dose and then gradually increase over months until you're eating whole peanuts (4-12 of t…

This is basically what most allergy treatments are. Start with 1/1000th of a peanut and gradually increase. It's a simple concept that's been used for nearly a century for other allergens. I did it for cat allergies over a decade ago. Developed them in college after growing up with cats. I have cats now.

Re: Peanut allergy cured in majority of children in immunotherapy trial

#65
post #39

My daughter has Celiac disease. It was diagnosed at age 4 when her growth chart showed she did not gain a single pound and grew ¼" from age 3-4. We did a biopsy of her small intestine and it was completely smooth. (Should be almost like velvet) Herblood levels also showed high sensitivity to gluten. We have her on a strict gluten free diet and she has since followed the growth chart perfectly. However she is sensitiv…

Are you familiar with ImmusanT Nexvax2? In a trial to treat celiac.

http://www.immusant.com/patient-resources/clinical-trials.ph...

Re: Peanut allergy cured in majority of children in immunotherapy trial

#66
post #39

My daughter has Celiac disease. It was diagnosed at age 4 when her growth chart showed she did not gain a single pound and grew ¼" from age 3-4. We did a biopsy of her small intestine and it was completely smooth. (Should be almost like velvet) Herblood levels also showed high sensitivity to gluten. We have her on a strict gluten free diet and she has since followed the growth chart perfectly. However she is sensitiv…

One of my friends in high school had celiac & peanut allergies. The kids / schools were super accommodating, I know everyone is going to have different experiences but I wish you both a good life. I think for him it ended up being more of an issue while young, gaining the discipline to really know & explain to people his condition and how it was important they just know and think about it. On a certain level it creates an interesting dynamic into figuring out if people are really listening & absorbing knowledge, in a weird way it’s probably given him a very unique life experience.

You’re also right to hope for better treatment paths for her future. Compared to even when we grew up the cultural knowledge of celiac is so much better. And since it’s something that’s been discovered to be not nearly as rare as once thought, the research dollars have caught up. These are all signs that point to a bright future :-)

Re: Peanut allergy cured in majority of children in immunotherapy trial

#68
post #6

Could this be made to work on allergies in general? The article suggests it could at least be used for food allergies in general.

Immunotherapy can work for allergies in general, but for non-food allergies is quite inconvenient (several shots per month for years)

My wife was really allergic to cats, but a year living with our kitten and being bitten and (playfully) scratched - and she was pretty much cured - which she puts down to DIY immunotherapy

Re: Peanut allergy cured in majority of children in immunotherapy trial

#69
post #39

My daughter has Celiac disease. It was diagnosed at age 4 when her growth chart showed she did not gain a single pound and grew ¼" from age 3-4. We did a biopsy of her small intestine and it was completely smooth. (Should be almost like velvet) Herblood levels also showed high sensitivity to gluten. We have her on a strict gluten free diet and she has since followed the growth chart perfectly. However she is sensitiv…

I have Celiac. Unfortunately immunotherapy is not currently done in a way that would make much of a difference for us. Celiac is typically an autoimmune response to Gliadin protein as a result of human leukocyte activation genes HLA-DQ2.2/2.5 or HLA-DQ8. In either case, it is happening at the cellular level for every cell that comes into contact with the protein. The intestines are hard hit mostly because they spend the longest time with exposure. I found for the first year or so I simply could not eat anything made by a restaurant or friend because of cross contamination. My resilience went up over time though, it takes a few years for inflammatory activation to come back down to a subclinical level even if the gut repairs in 3-6 months. Gut bacteria change in response to all the immune activity, but damping the immune response would not necessarily fix the issue of the protein destroying the cells it comes into contact with. The immune response is therefore not entirely autoimmune in nature but necessary to protect the cells. The vili are being destroyed directly, essentially. You could develop a drug that would dampen the immune response (I think a few others posted links) but you could not realistically get to a point where you can eat gluten. The antigen will always destroy your cells, autoimmune response or not. Sensitivity depends on how many (one or two) of the HLA genes you have that react with gluten. I have one out of two so my reactions are less severe (only 2-3 days with symptoms). If you have both Celiac HLA genes, it will always and consistently harm you.

Re: Peanut allergy cured in majority of children in immunotherapy trial

#70
post #47

Earlier quoted context omitted.

Isn't Yogurt a common thingy in various countries. At least, in India it is known to have been used for a long time (specifically the clarified butter derived from the yugurt[1]). [1] https://en.wikipedia.org/wiki/Ghee

Ghee is clarified butter and has nothing to do with yogurt. Now, when the native to Bulgaria bacteria has been spread around the globe, yogurt is available worldwide, but not until recently.

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