Could someone who really wants to get rid of the GIL explain the appeal? As far as I understand, the only time it would be useful is when you have an application that is 1. Big enough to need concurrency 2. Not big enough to require multiple boxes. 3. Running in a situation that can not spare the resources for multiprocessing. 4. You want to share memory instead of designing your workflow to handle messages or workin…
Python multiprocessing doesn't work well with a lot of external libraries. For example, CUDA doesn't work across forks and many system resources can be shared across threads but not processes. Python objects must be pickled to be sent to another process, but not all objects can be pickled (including some built-in objects like tracebacks).
A lot of different parallel programming models can be built on top of threads (shared memory, fork-join, message passing), and to a certain extent they can be mixed. That's not true of Python multiprocessing, which only allows a narrow form of message passing. (It's also buggy, has internal race conditions, and easily leaks resources.)
The problem for CPython is that it may not be possible to remove the GIL without breaking the C API, and a lot of the benefit of Python is the huge number of high-quality packages, many of which use the C API.