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First Human Embryos Edited in U.S

technologyreview.com

81–90 of 292 posts

Re: First Human Embryos Edited in U.S

#81

Earlier quoted context omitted.

Where it comes from: https://en.wikipedia.org/wiki/Hippocratic_Oath

But in that sense it's not literal at all. Again, chemotherapy.

Sure, but read the link.

> It is often said that the phrase "First do no harm" (Latin: Primum non nocere) is a part of the Hippocratic oath. The phrase as such does not appear in the oath...

Re: First Human Embryos Edited in U.S

#82
post #80

Earlier quoted context omitted.

Most agree that it is unethical to purposely have a disabled/diseased child if it possible to not have a nondisabled one. In that case, I think it is quite ethical for this technology to be used on those with debilitating genetic defects. We’re in no rush to allow any genome editing other than that.

Hmm. Including myself, anyone with an IQ less than 2.5 sigmas above average, or with strong enough emotions to make bad decisions that contradict correct analyses, or with not enough ambition to want to attempt anything useful with their high IQ in the first place ... is thusly "debilitated" and should have been allowed genetic engineering.

That sounds like a top-down policy of required gene editing, which is a strawperson.

Re: First Human Embryos Edited in U.S

#83

Earlier quoted context omitted.

But in that sense it's not literal at all. Again, chemotherapy.

Sure, but read the link. > It is often said that the phrase "First do no harm" (Latin: Primum non nocere) is a part of the Hippocratic oath. The phrase as such does not appear in the oath...

Im making over $7k a month working part time. I kept hearing other people tell me how much money they can make online so I decided to look into it. Well, it was all true and has totally changed my life. This is what I do, ====http://www.smartfinancemedia.com/?682

Re: First Human Embryos Edited in U.S

#84
post #11

We would need a very particular set of conditions for embryonic editing to be justifiable under a medical dogma that aims to "do no harm." Both parents would need to carry a large common set of recessive deleterious alleles, as this would make embryonic selection of non-carriers very difficult. Then we would need the editing system to be so reliable as to not introduce off-target mutations. In a preimplantation setti…

I'm not certain where the premise that our medicine must "Do no harm" comes from. Chemotherapy, for example, is known for being extremely toxic and harmful, yet the justification is that it often yields better outcomes than no treatment. Why can we not use the same justification for editing DNA? Honestly some therapies cause mutations by design, as some cancers are less capable of DNA repair. I do see one argument, h…

"Do no harm" speaks to intent, as in harm can't be the intent. Making great discoveries doesn't justify doing harm. Mengele (the Nazi) comes to mind.

Re: First Human Embryos Edited in U.S

#86

Earlier quoted context omitted.

I'm not certain where the premise that our medicine must "Do no harm" comes from. Chemotherapy, for example, is known for being extremely toxic and harmful, yet the justification is that it often yields better outcomes than no treatment. Why can we not use the same justification for editing DNA? Honestly some therapies cause mutations by design, as some cancers are less capable of DNA repair. I do see one argument, h…

Where it comes from: https://en.wikipedia.org/wiki/Hippocratic_Oath

It’s a myth that doctors even take this oath. There might be some modern version taken, but it is a symbolic pledge, not a legal requirement. Laws and committees cover issues of ethics these days.

Re: First Human Embryos Edited in U.S

#87
post #11

We would need a very particular set of conditions for embryonic editing to be justifiable under a medical dogma that aims to "do no harm." Both parents would need to carry a large common set of recessive deleterious alleles, as this would make embryonic selection of non-carriers very difficult. Then we would need the editing system to be so reliable as to not introduce off-target mutations. In a preimplantation setti…

I'm not certain where the premise that our medicine must "Do no harm" comes from. Chemotherapy, for example, is known for being extremely toxic and harmful, yet the justification is that it often yields better outcomes than no treatment. Why can we not use the same justification for editing DNA? Honestly some therapies cause mutations by design, as some cancers are less capable of DNA repair. I do see one argument, h…

> I'm not certain where the premise that our medicine must "Do no harm" comes from.

It comes from the hippocratic oath. "I will apply dietetic measures for the benefit of the sick according to my ability and judgment; I will keep them from harm and injustice."

Re: First Human Embryos Edited in U.S

#88

Earlier quoted context omitted.

I can’t imagine anybody in their right mind would create a genome that had a DRM. Furthermore, would you sign up for a procedure like that? Also it’s a violation of somebody’s human rights to stop them from reproducing! What is really happening is that normal copies of the human genome are being incorporated. Which are then passed on to your sperm/ovum.

It's already done for some genetically-modified crops. I don't know about the state of practice for animals.

While the technology exists, so-called "terminator genes" have not been implemented due to opposition from anti-GMO activists and other groups: https://en.wikipedia.org/wiki/Genetic_use_restriction_techno...

Re: First Human Embryos Edited in U.S

#89
here's a TODO list i made for possibly interesting genome editing targets: http://diyhpl.us/wiki/genetic-modifications/

Many of these have low demonstrated correlation or significance so don't just blindly load everything on that document into your at-home CRISPR kit http://www.the-odin.com/gene-engineering-kits/ but it should be a good starting point for thinking about what can be modified, improved, disimproved, etc.

Re: First Human Embryos Edited in U.S

#90

Earlier quoted context omitted.

Where it comes from: https://en.wikipedia.org/wiki/Hippocratic_Oath

It’s a myth that doctors even take this oath. There might be some modern version taken, but it is a symbolic pledge, not a legal requirement. Laws and committees cover issues of ethics these days.

>It’s a myth that doctors even take this oath.

Not really:

"In a 2000 survey of US medical schools, all of the then extant medical schools administered some type of profession oath. Among schools of modern medicine, sixty-two of 122 used the Hippocratic Oath, or a modified version of it."

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