I still see it as worse than a normal application being compromised.
When Ring 0 is compromised, there is no alert or anything to protect the app from compromise. If there is an exploit, it's game over.
However, in Ring 3 and a normal kernel, you get various protections that allow the kernel to recognize some attacks and shutdown the application immediately or even shutdown the kernel.
This prevents a compromised app from running to some extend.
A unikernel cannot do this. If the app is compromised and I don't notice and don't restart it...
Even worse, the attacker could use it as leverage to infect other unikernel based instances of the app to gain some permanence against restarts by simply reinfecting when an instance goes down.
The unikernel is not userspace, not even conceptually. The hpyervisor will not shutdown the app unless it executes illegal instructions. The kernel will shutdown misbehaving programs more easily.