Wow, I don't think I would've even considered such an attack...
DNSSEC, HSTS and Certificate Pinning would've made it more difficult to abuse this, but I guess it would've been pretty easy to get valid SSL certificates for all your favourite .io domains.
Let's try to play malicious party here:
Phase A: First set up a simple DNS forwarder playing by the rules and answering requests as we should (as to not get any unwanted attention).
Gather usage statistics.
Phase B: Crawl the list of most-used domains to see if there are any valuable targets without HTTPS (port 443 is closed). Alternatively/additionally see if there are API subdomains used by software other than browsers (of which a few won't have annoying features like Cert Pinning - golang's DNS resolver for example afaik doesn't do DNSSEC).
Pick some medium to high level targets where the attack might go undetected for at least some time.
Phase C: MitM time! Get certificates for the target domain(s) of your choice and get to work. Start with only a few percent of the requests to not draw too much attention (and to avoid the majority of their traffic coming from a single IP (range) all of a sudden)
Obfuscate the attack by acting like a third party app or something simply doing requests for their users.
Congratulations on finding the vulnerability (and thanks for looking for that kinda stuff in the first place).