Earlier quoted context omitted.
Pl-238 is very expensive to produce. We are talking millions/kg.
That's a trivial cost when we're talking about sending things to Mars. The Curiosity rover has around 5kg of Pu-238. NASA estimates that restarting production will cost $6M/kg[1]. The total cost of the MSL program is 2.5 billion[2]. That's $30 million out of 2.5 billion, or 1.2%. NASA has also been buying Pu-238 from the Russians at around $1.5 million/kg[3], which would be $7.5 million for Curiosity, or 0.3% of the…
I'm sure the demand for a colony would scale pretty fast to 100kW or more. Now we are talking about Billions.
So I think that your original point that cost for Pu-238 is not an issue for a colony is wrong.
Small reactors are a much better option as a single ton of fuel could supply a colony with a few MW for decades. You just have to make sure that the largest part is less than 37 tons so it can be transported with a Long March 9.