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How Aging Research Is Changing Our Lives

aging.nautil.us

51–60 of 63 posts

Re: How Aging Research Is Changing Our Lives

#51
post #5

Earlier quoted context omitted.

While immorality might be a stretch, CRISPR is certainly going to change how we think about longevity in a sensationally magical way.

How? CRISPR is overhyped. We don't even understand aging sufficiently enough.

We don't currently is not he same as we won't ever.

Re: How Aging Research Is Changing Our Lives

#52
post #22

Earlier quoted context omitted.

Yeah, I do mean the whole package. I have a copay too and I maybe shouldn't worry about it, but I do have a fear that using insurance too much for routine stuff will bite me later. $20 isn't much, but the doctor's office charges $100 for that, and I'd love to chat like twice a month. I assume that I end up paying the full price eventually. As it stands I make it in once or twice a year. Even if I paid full price with…

If you have no symptoms then what on earth would you have to talk about with your GP twice a month? I think you overestimate the insider-expertise the medical profession possesses when it comes to optimizing health.

> If you have no symptoms then what on earth would you have to talk about with your GP twice a month?

I feel like this illustrates my point quite nicely. I'm not sure, but the addition of "on earth" makes your sentence sound incredulous and rhetorical rather than a genuine question, more of a statement that without symptoms there can't possibly be anything to discuss. Are you by chance under 30?

The definition of whether something's wrong when I visit the doctor is how much pain there is. When they ask what's wrong they always give me a green xerox of a questionnaire that has me circle the number between 1 and 10 rating my pain level. If that number is less than 5, they schedule differently. Non-emergency may mean 2-3 weeks before I get a visit. If it's 1 or 0, they start asking if you really need to see the doctor at all and start giving you online resources.

Ever do any maintenance on your car or your computer when nothing's wrong with it now but you guess might be later if you don't? I have. Ever change oil or free up some disk space? Have you ever optimized some code before you actually measured a performance problem? I have. What are the reasons that we would ever do that or talk to anyone about it before there are actual symptoms?

Have you ever googled a health question to see what other people are doing? I have and I happen to know that Google's index has a lot of content that answers minor and major health and medicine questions. The existence and popularity of health advice online and websites like WebMD suggests you might be underestimating how many people would enjoy the chance to chit-chat with their doctor more often, just to ask stupid questions.

Have you ever just been curious about how things in your body work? Sometimes I know what to do with my body, I just want to learn why it's doing something, and learn it from somebody who went through training. For some topics, I'd rather skip the part where I google it and try to sift through the 90% of bullshit online where people just make up stuff, and talk to someone I trust instead.

I do get the feeling you might be making assumptions about what I said and what kind of questions I was talking about. I'm not sure what you're imagining, but I probably would run out of questions like "how many calories should I eat?" and "should I exercise?" pretty quickly. The body has a lot of moving parts though, and once you have a few surgeries, once you're over 40 and weird things start to happen, once you get curious about why some part of your body isn't doing exactly what you expect, you might end up wanting to ask your doctor some questions about your joints & muscles, or about your esophagus & stomach, or the health of your children, or your hair & eyesight, or your skin or toenails, or whether your family history about this or that is likely to affect you.

I've only just turned 40 and I suppose to be fair, when I was younger I might have felt the same way you do. But my body is changing and my desire to stay on top it is increasing. I've always been fairly healthy, and I know what to do to stay healthy, but in the last decade my body reacts differently to exercise than when I was younger. I've hit a couple of joint issues going to the gym that compromise my ability to do certain exercises. In the last 5 years I've hit some knee problems when running that compromise my ability to run longer distances. I've done minor damage my neck and back mountain biking and skydiving. I'm starting to experience side effects from the surgeries I've had in my life. My digestion is changing and I can't eat all the same food I used to without "adverse" effects. I would love to get regular advice on how to tune myself given the problems I have, often from a sports doctor, but like I said I don't seek appointments for every question that pops into my head because our medical system doesn't really support education and regular preventive care.

Eric Verdin is spot on, in my opinion, we have sick care, not health care.

Re: How Aging Research Is Changing Our Lives

#53
post #39
post #22

Earlier quoted context omitted.

Yeah, I do mean the whole package. I have a copay too and I maybe shouldn't worry about it, but I do have a fear that using insurance too much for routine stuff will bite me later. $20 isn't much, but the doctor's office charges $100 for that, and I'd love to chat like twice a month. I assume that I end up paying the full price eventually. As it stands I make it in once or twice a year. Even if I paid full price with…

Some insurers like UnitedHealthCare provide a free subscription to http://healthiestyou.com/ . HealthiestYou via UHC is a service where you book an appointment via their app and the doctor calls you back within a few minutes. You can book unlimited appointments at no additional charge. You do not talk to your regular GP but you do get access to real doctors.

This might be what I want, and it looks awesome in any case. Thanks for the link, I will be calling my insurance company to see if I'm covered.

Re: How Aging Research Is Changing Our Lives

#54
post #44

Earlier quoted context omitted.

> There is a ton of information of healthy living Where is this "ton of information on healthy living" and what level of evidence do you have for it? I don't doubt that there is a set of things that people can do to be healthy. I do not think that there is much information about what those steps are. Again, there is plenty of writing on the topic, but little information.

I suppose this is pretty subjective and depends on your level of knowledge on the issues, but I feel that healthy living is more or less a solved problem from a "what to do" standpoint. The main problem is breaking people of unhealthy lifestyle habits while educating them on healthier habits (see books like Power of Habit for habit formation and modification). I don't have links handy (edit: apparently I have a few)…

The level of evidence for most of these recommendations is quite low. That doesn't make this bad advice. In fact, most of it is probably good advice. But it does explain why the GP's physician is not going to be discussing this in detail.

Re: How Aging Research Is Changing Our Lives

#55
post #18

Great article, this is the first one on aging I've read in a while that has it's head on straight and isn't trying to make weasel arguments that suggest aging cures are just around the corner. Happy to see a clear distinction between lifespan and longevity, so many people like to leverage confusion between those concepts to argue that medical advancements have improved longevity, like Ray Kurzweil does. > People talk…

There is just not much information about healthy living (though there is plenty of noise). Observational data suggests that eating a diverse diet (but not too much food that you become overweight), being moderately active, limiting alcohol intake, and avoiding smoking is healthy. Observational data can be confounded, but it's not like we have (or are likely to have) randomized controlled trials of different approache…

> How long should the trial run before you decide that the null hypothesis is true?

As long as your experimental design says you should. You don't have a scientific outcome until the trial is over, so stopping makes no sense on a scientific basis.

Re: How Aging Research Is Changing Our Lives

#56
post #52

Earlier quoted context omitted.

If you have no symptoms then what on earth would you have to talk about with your GP twice a month? I think you overestimate the insider-expertise the medical profession possesses when it comes to optimizing health.

> If you have no symptoms then what on earth would you have to talk about with your GP twice a month? I feel like this illustrates my point quite nicely. I'm not sure, but the addition of "on earth" makes your sentence sound incredulous and rhetorical rather than a genuine question, more of a statement that without symptoms there can't possibly be anything to discuss. Are you by chance under 30? The definition of whe…

> I've hit a couple of joint issues going to the gym that compromise my ability to do certain exercises. In the last 5 years I've hit some knee problems when running

The running and lifting communities do an ok job giving people basic safety training, but the way people do these repetitive motions over and over and over for years without variation will frequently lead to injuries in the long term. It's still a net gain for health, but there's something about just the intention to be "a runner" or "a lifter" that sets you on a path to injury.

The alternative is movement practices that span a much wider range of motions. Tai Chi is a good example. Yoga probably is not, based on the way your average teacher will teach it (goal-oriented, fast, and repetitive).

But really if you want to limit your exposure to injury, you need to learn to be active all day long, to find exercise and resistance in everything you do, learn to read which activities your body needs more of, and go seek them out, and learn how to heal from things you're doing too much of.

Runners World can't really advise you on that because if it's not running it's not really on topic.

Re: How Aging Research Is Changing Our Lives

#57

Great interview. I thought his comments about the upper limits of human lifespan were especially interesting: > There currently is an upper limit, and the upper limit is probably around 115, 120. You have a very large number—100 billion people to choose the number of people that have ever lived—and you have only one who has made it through to 122, Jeanne Calment. The second oldest was 119. It does seem there is an up…

Yeah, I wish there was more real talk about this too. I can certainly imagine that new technologies could turn a graph that's levelling off into a hockey stick. I think those are interesting theories.

But there's no evidence that will happen. I can imagine being headed towards 150-year lifespans, there's just no evidence we're on that track right now.

Re: How Aging Research Is Changing Our Lives

#58

Earlier quoted context omitted.

There is just not much information about healthy living (though there is plenty of noise). Observational data suggests that eating a diverse diet (but not too much food that you become overweight), being moderately active, limiting alcohol intake, and avoiding smoking is healthy. Observational data can be confounded, but it's not like we have (or are likely to have) randomized controlled trials of different approache…

> How long should the trial run before you decide that the null hypothesis is true? As long as your experimental design says you should. You don't have a scientific outcome until the trial is over, so stopping makes no sense on a scientific basis.

Of course. The problem is that trials when your effect size is small are expensive. A trial looking at longevity outcomes for young healthy people would require decades of follow-up. The expense would be enormous, and the results would come generations later. Really have to hope you've asked the right questions.

Re: How Aging Research Is Changing Our Lives

#59
post #5

Great interview. I thought his comments about the upper limits of human lifespan were especially interesting: > There currently is an upper limit, and the upper limit is probably around 115, 120. You have a very large number—100 billion people to choose the number of people that have ever lived—and you have only one who has made it through to 122, Jeanne Calment. The second oldest was 119. It does seem there is an up…

While immorality might be a stretch, CRISPR is certainly going to change how we think about longevity in a sensationally magical way.

That would be great! The hundreds of off-target mutations thing is a little bit concerning, however.[1] I hope this doesn't turn out to stymie the potential for a delightfully scifi future.

[1] https://sciencealert.com/turns-out-crispr-gene-editing-can-c...

Re: How Aging Research Is Changing Our Lives

#60
post #14

Earlier quoted context omitted.

Did you read the article? "First, if you hear the word immortality, just run" No one is talking about immortality here.

I'm making the cases for it! After all, it's the culmination of all medical research, whether intended or not. What happens when science "solves" aging and disease? What will we call the state where people just don't die unless killed?

Statistically people will still die. I imagine a life insurance actuary could provide an expected life span if all medical causes of death were removed. I doubt it would be more than a thousand years.
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