I find that, with few exceptions, Kindle programming ebooks are annoying and unpleasant. Some of the "textbook"-mode ones (where you can highlight diagrams and not just text) are tolerable on a Chromebook in tablet mode, but just barely.
And there's no way I'm going to pay $399/year for Safari, not when I'm currently spending $0-50/year, and certainly not for the privilege of using what people tell me is a mediocre mobile app. So going forward, this means that I'll buy maybe one O'Reilly book every other year through Amazon.
Does this also mean that O'Reilly is no longer going to be offering "early release" books for people who don't buy Safari? I think that something like 90% of my technical book purchases in the last 10 years were early release.