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Moderate drinking associated with atrophy in brain related to memory, learning

washingtonpost.com

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Re: Moderate drinking associated with atrophy in brain related to memory, learning

#121

But they define "moderate" as 2 drinks/day for a man. That is 14 drinks a week which puts you in the second highest decile for Americans! https://www.washingtonpost.com/news/wonk/wp/2014/09/25/think...

I would consider moderate drinking to be 4-5 drinks a week (drinking socially weekends). 2 drinks/night is practically getting drunk/tipsy every night. In what world is that moderate?

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#122
post #45

Earlier quoted context omitted.

According to the study which was linked in another comment [1] they were using the standard defined in [2]. This site shows that one pint of lager counts as 2 units of alcohol. One pint is 19.2 oz [3]. A bottle of beer is usually 12 oz, aka 5/8 of a pint, aka 1.25 units of alcohol. I trust the source over the science journalist. [1] http://www.bmj.com/content/357/bmj.j2353 [2] https://www.alcoholconcern.org.uk/unit-c…

One British pint is 568mL, and one "unit" of alcohol is 10mL -- I think the latter might be a European standard. That makes a ½pt (284mL) beer, at 3.5%, almost exactly 10mL of alcohol (284*0.035 = 9.94). The average beer is stronger than it was 20 years ago, but there's still a feeling that 1pt = 2 units in Britain.

Wow. 3.5% beer...is almost unheard of in the USA, especially in the face of the overwhelming popularity of “craft” and “micro” brews which often click in above the 6% mark

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#123

But they define "moderate" as 2 drinks/day for a man. That is 14 drinks a week which puts you in the second highest decile for Americans! https://www.washingtonpost.com/news/wonk/wp/2014/09/25/think...

I would consider moderate drinking to be 4-5 drinks a week (drinking socially weekends). 2 drinks/night is practically getting drunk/tipsy every night. In what world is that moderate?

Moderation is contextual.

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#124
post #22

Earlier quoted context omitted.

The article says a 12 oz beer (slightly larger than the standard 330ml beer) is 1 drink for the purposes of the study.

Right, but beer varies widely in alcohol content. One "standard beer" might be defined as 12 oz / ~330ml @ 4.5% alcohol by volume, but many IPAs are 6-7% or greater, and in most U.S. states you can find lots of beer in excess of 10% ABV.

“Lots of beer in excess of 10%” is a bit of a stretch. I think it’s more common to see the 6-7% range represented with something pushing 10% being the outlier.

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#125
post #41

Alcohol is getting a pretty bad rap to me the more I read about it. After reading this I was curious about ways to _increase_ hippocampal function. According to [0] it seems like exercise can increase hippocampal function. Another link I can't find again since I found it on my phone and am now on my laptop indicated things like learning languages, and an omega 3 rich diet can also help. This is good news for me since…

Here is some more reading to further persuade you - SECRET FSB LECTURE: Why Putin doesn't drink alcohol [0].

This clip has Putin back in 1999, Chechen War, raising a glass with the troops to then put the glass down and command his men to get back to work, deferring the drinking until the job is done. The supposed 'secret FSB lecture' explains how alcohol strips the outer 'oily' layer from blood vessels causing things to go wrong in the narrow capillaries of the brain. The clip ends with the former president Yeltsin dancing like an idiot and generally being out of it due to the booze.

Whether you see Putin as friend or foe matters not, when it comes to attitude towards alcohol Putin sets quite an example. He also challenges the belief that there is something innately Russian about getting sloshed on alcohol - it doesn't have to be that way.

I enjoy thinking more than drinking so drinking the work trip to the boozer is always a 'do I really have to?' thing for me, almost a chore. From this perspective of 'extremely moderate moderation' I do wonder why it is universally normal (outside of Utah and the Muslim world) for there to be a company 'tab'. An employer that doesn't do that (even xmas party) would be considered miserable and miserly. However, imagine if you had a company where cigarettes were dished out freely on a Friday afternoon and something that you could put on expenses. Any employer doing that would be considered reckless. So why is it different with alcohol?

[0] - https://www.youtube.com/watch?v=6WLfkEEDOzI

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#127
post #42

Earlier quoted context omitted.

> 550 civil servants Bureaucracy causes brain damage. Those with heavier damage took refuge in alcohol.

I'm not sure if you are trying to be funny - if so, you've succeeded. However, this also reads to me like a very plausible explanation. I like the idea of specifically studying this component further.

Agreed; I've seen studies relating stress (especially over time) to decrease of cognitive function. I've observed the same in myself.

Fwiw, two glasses of wine a week is what I'd call moderate consumption of alcohol. Where I live, most people drink far too much.

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#128

As a stats man, before I read the article I said to myself: "bet it's from a survey". With that kind of methodology, I imagine the "moderate" drinkers are going to contain the group of people who said they (frequently) drink, but not that much. I'd be willing to bet there will be a relationship between reporting that you drink frequently and the negative effects of alcohol that will outweigh the attempt to self repor…

As a drinker, I think there's the issue of how those 14 drinks are distributed over the week. IMO 2 drinks a day is pretty doable, but 14 drinks every Friday night over 30 years sounds like a terrible idea.

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#129

But they define "moderate" as 2 drinks/day for a man. That is 14 drinks a week which puts you in the second highest decile for Americans! https://www.washingtonpost.com/news/wonk/wp/2014/09/25/think...

Americans are practically teetotallers, apparently?

It's unevenly distributed

Re: Moderate drinking associated with atrophy in brain related to memory, learning

#130

As a stats man, before I read the article I said to myself: "bet it's from a survey". With that kind of methodology, I imagine the "moderate" drinkers are going to contain the group of people who said they (frequently) drink, but not that much. I'd be willing to bet there will be a relationship between reporting that you drink frequently and the negative effects of alcohol that will outweigh the attempt to self repor…

I believe it's the same study that was on here a few weeks ago, it's from brain scans + tests. 550 people over 30 years, same number, same years. Self-reported consumption.

Actual study: http://www.bmj.com/content/357/bmj.j2353

The study is pretty detailed, but there are some oddities in the results, higher IQs drank more on average and lost more, people who drank heavily lost less than those who drank moderately.

This was based in the UK, in one community, middle-class, civil servants, predominantly men, average age 43 at start of study (and I would guess almost all white, though they don't say it).

Unsafe drinkers differed from safe drinkers by having a higher premorbid IQ, a higher percentage of men and smokers, and higher Framingham risk scores

Some of the interesting results:

Higher alcohol consumption over the study predicted faster decline on lexical fluency but not semantic fluency or word recall.

People drinking has a % greater reduction from their baseline in lexical fluency per year:

    7-21 units 0.6% per year (16% over 30 years)
!! These figures are odd and seemingly don't add up. Is it just bad rounding? Are their graphs based on these wrong figures? !!

Their conclusion doesn't highlight that it doesn't seem to matter how much you drink in terms of lexical fluency, it's that you drink at all?

I don't really understand the section titled "Grey matter". 3.4 odds in lighter drinkers, 5.8 odds in heavier drinkers? They don't really explain what that means.

Edit: having now listened to the audio it seems there was some technical problem with the white matter measurement, but they say they saw a decline.

Previous discussion: https://news.ycombinator.com/item?id=14508201

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