Earlier quoted context omitted.
I need CUDA drivers for what I am working with, and I have found no way to install it in Guix. Otherwise, it looks interesting enough. (Sexps are usually not my first choice, I think it is a "lazy option" for people who do not want to write parsers / design their own syntax. Even then, they are better than current Nix expressions).
AFAICT, there are 2 major differences between Nix and Guix. Language choice is the obvious one. The other is that Guix takes a hard-line stance on the GNU philosophy and therefore refuses to distribute pre-compiled binaries. I don't think CUDA will ever be an option on Guix.
It's a volunteer-run service. It makes sense they don't want to host your proprietary binaries