Earlier quoted context omitted.
That seems like a white pattern to me.
If only delivering mail to existing email addresses is a white pattern, sure.
If I configure me.example.com to accept emails matching the pattern "memail42@me.example.com", then I can generate as many on-the-fly unique emails as I want, without maintaining any lists, and without catch-all forwarding of random spam to my inbox.
If I use me+anything@me.example.com, I get the same exact feature, but the downside is "+anything" is recognized by some and either disallowed or used to generate more patterns.
If I use subdomains (like anything@me.example.com) I have the spam issue.
With a white pattern scheme, you can choose your own pattern (so sites can't really catch on), not have to maintain any lists, and avoid spray-and-pray spam.