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Two new peanut allergy treatments are on the verge of approval

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Re: Two new peanut allergy treatments are on the verge of approval

#31

Never heard about peanut allergy here in India, looks like a first world problem.

It largely is. That is, globally peanut is among the most common severe food allergies, but it's still fairly rare. But in the developed world (IIRC, particularly the US) popular guidance to mitigate the risk of peanut allergies in very young children (who can't communicate symptoms.as effectively, so, if they have an allergy, are at greater risk of consuming more and/or having treatment delayed) was to avoid any exposure.

It turns out that that guidance actually increased the incidence of severe peanut allergies immensely, because it made it much more likely that when people were exposed later, they would develop an allergy, and peanut allergy is far less common where children are usually exposed at a young age.

Re: Two new peanut allergy treatments are on the verge of approval

#32
post #30

Earlier quoted context omitted.

According to my pediatrician, research shows that exposing children to peanuts earlier decreases the likelihood of a child developing a peanut allergy.

Maybe, maybe not. It's just unclear. My wife ate a ton of peanut butter during her pregnancy. One would think it would have protected our son, but it didn't. He's now eight and the peanut allergy is getting worse.

The evidence is pretty convincing. You saying "it's just unclear" is just you misinterpreting "decreases the likelihood" to include "to zero".

Re: Two new peanut allergy treatments are on the verge of approval

#33

Money quotes: > Big Pharma was unmoved, believing it would be impossible to patent a medicine that was essentially a ground-up peanut. > [One of the companies working on the issue] has ties to the food industry, which has a vested interest in finding treatments for allergies. Make of this what you will.

1. Companies investing hundreds of millions want to ensure a return 2. Food companies want customers to eat (and not die from) their products.

Groundbreaking, I know.

Re: Two new peanut allergy treatments are on the verge of approval

#34

Never heard about peanut allergy here in India, looks like a first world problem.

Possibly. Or the people who have it just die for unexplained reasons.

you don't need Gregory House to diagnose an anaphylactic shock

Re: Two new peanut allergy treatments are on the verge of approval

#35
post #9

Last year I learned that 20% of adults who were diagnosed with a peanut allergy outgrow it after childhood. It is worth getting tested again if you grew up with a peanut allergy. I had signed up for a trial of one of these drugs. Having grown up in the 80s with a severe peanut allergy that required the use of the epipen more than a few times I was keen for anything that could help, even just something that would less…

On the other (anecdata) hand, my wife has been severely allergic to peanuts for decades, and still is... she can tell if someone is eating peanuts nearby .

This is me but with coffee. And coffee is everywhere.

Re: Two new peanut allergy treatments are on the verge of approval

#36

Never heard about peanut allergy here in India, looks like a first world problem.

There's something called the Hygiene Hypothesis which states that "a lack of early childhood exposure to infectious agents, symbiotic microorganisms (such as the gut flora or probiotics), and parasites increases susceptibility to allergic diseases by suppressing the natural development of the immune system".[1]

In other words, it could mean that excessive hygiene in childhood could be causing allergies.

[1] - https://en.wikipedia.org/wiki/Hygiene_hypothesis

Re: Two new peanut allergy treatments are on the verge of approval

#37
Another interesting read: "about 80 percent of the children who received the peanut protein plus probiotic treatment were able to consume about 0.1 ounces (4 grams) of peanut protein without a reaction. What's more, when the parents of these children were interviewed about three months after the study ended, most said that their child was still able to include some peanuts in his or her diet (varying from five peanuts to 3 tablespoons of peanut butter a week)."

http://www.livescience.com/49638-peanut-allergy-treatment-pr...

Re: Two new peanut allergy treatments are on the verge of approval

#38
post #33

Money quotes: > Big Pharma was unmoved, believing it would be impossible to patent a medicine that was essentially a ground-up peanut. > [One of the companies working on the issue] has ties to the food industry, which has a vested interest in finding treatments for allergies. Make of this what you will.

1. Companies investing hundreds of millions want to ensure a return 2. Food companies want customers to eat (and not die from) their products. Groundbreaking, I know.

Of course it's reasonable within the system. Inward and outward reasonableness of a system are sometimes quite orthogonal.

Re: Two new peanut allergy treatments are on the verge of approval

#40

Earlier quoted context omitted.

According to my pediatrician, research shows that exposing children to peanuts earlier decreases the likelihood of a child developing a peanut allergy.

I gave my son a bite of the peanut butter cookie I was eating, when he was six months old, nearly killed him. So this "expose them early and it's not a problem" maybe true part of the time for some allergens, but certainly not all the time for all allergens. Edit: Down voters care to comment?

I didn't downvote, but "expose them early and it's not a problem" isn't the advice, the advice is that early exposure reduces the chances of allergies.

In any case, it is a statistical assertion, not a guarantee.

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