Our understanding of the way the body handles salt may be wrong
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Re: Our understanding of the way the body handles salt may be wrong
#2That is interesting.
I see an advantage this adaption offers when trapped with only salty sea water.
Excessive salt intake may occur naturally when in the ocean for whatever reason.
When this reduces thirst and offers an (internal) alternative for water this may help you survive until you strand somewhere to find fresh water.
Not the worst trait evolution could select for.
Re: Our understanding of the way the body handles salt may be wrong
#3That is interesting. I see an advantage this adaption offers when trapped with only salty sea water. Excessive salt intake may occur naturally when in the ocean for whatever reason. When this reduces thirst and offers an (internal) alternative for water this may help you survive until you strand somewhere to find fresh water. Not the worst trait evolution could select for.
There is a negative side to it, you use up more calories.
(unrelated, I think fast food companies are already aware of the more hunger from salty food.)
Re: Our understanding of the way the body handles salt may be wrong
#4And, Dr. Titze said, high glucocorticoid levels are linked to such conditions as osteoporosis, muscle loss, Type 2 diabetes and other metabolic problems.
And cystic fibrosis, which is perhaps best tldr'd as a salt wasting condition, frequently leads to Cystic Fibrosis Related Diabetes, which is neither type 1 nor type 2 diabetes.
Re: Our understanding of the way the body handles salt may be wrong
#5I think Thor Heyerdahl or someone on one of his crews noted that when they added seawater to the freshwater to make it last longer it also made them less thirsty.
IIRC they thought it was an interesting observation since it was against all common understanding, but I don't think they ever came close to a solution to why.
Re: Our understanding of the way the body handles salt may be wrong
#6And, Dr. Titze said, high glucocorticoid levels are linked to such conditions as osteoporosis, muscle loss, Type 2 diabetes and other metabolic problems. And cystic fibrosis, which is perhaps best tldr'd as a salt wasting condition, frequently leads to Cystic Fibrosis Related Diabetes, which is neither type 1 nor type 2 diabetes.
CFTR, being a chloride channel, most likely leads to diabetes as a consequence of its effects on the voltage-regulated insulin release in beta cells from glucose sensing. [1]
It strikes me as unlikely to be related to the salt-wasting that occurs from failure to reabsorb chloride in the epithelium.
Re: Our understanding of the way the body handles salt may be wrong
#7This didn't surprise me so much. In several hot countries I have noted people taking salt to relieve thirst. In Mongolia I drank heavily salted tea (the usual there) all summer and it becomes quite natural.
Maybe I'm missing some of the subtleties here?
Re: Our understanding of the way the body handles salt may be wrong
#8And, Dr. Titze said, high glucocorticoid levels are linked to such conditions as osteoporosis, muscle loss, Type 2 diabetes and other metabolic problems. And cystic fibrosis, which is perhaps best tldr'd as a salt wasting condition, frequently leads to Cystic Fibrosis Related Diabetes, which is neither type 1 nor type 2 diabetes.
CFTR, being a chloride channel, most likely leads to diabetes as a consequence of its effects on the voltage-regulated insulin release in beta cells from glucose sensing. [1] It strikes me as unlikely to be related to the salt-wasting that occurs from failure to reabsorb chloride in the epithelium. 1 = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104438/
I think it is probably a lot more complicated than that. CF does a great many things to the body. It is an inflammatory condition and I have seen multiple articles linking diabetes and inflammation. People with CF tend to be seriously underweight and I have recently seen articles that link inadequate muscle protein to insulin resistance. There is no doubt more than that going on, those are just a couple of things that occur to me off the top of my head.
Re: Our understanding of the way the body handles salt may be wrong
#9Earlier quoted context omitted.
CFTR, being a chloride channel, most likely leads to diabetes as a consequence of its effects on the voltage-regulated insulin release in beta cells from glucose sensing. [1] It strikes me as unlikely to be related to the salt-wasting that occurs from failure to reabsorb chloride in the epithelium. 1 = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104438/
I think it is probably a lot more complicated than that. CF does a great many things to the body. It is an inflammatory condition and I have seen multiple articles linking diabetes and inflammation. People with CF tend to be seriously underweight and I have recently seen articles that link inadequate muscle protein to insulin resistance. There is no doubt more than that going on, those are just a couple of things tha…
"I think it is probably a lot more complicated than that."
That's an evergreen, accurate response to anything in human biology!
Re: Our understanding of the way the body handles salt may be wrong
#10Earlier quoted context omitted.
I think it is probably a lot more complicated than that. CF does a great many things to the body. It is an inflammatory condition and I have seen multiple articles linking diabetes and inflammation. People with CF tend to be seriously underweight and I have recently seen articles that link inadequate muscle protein to insulin resistance. There is no doubt more than that going on, those are just a couple of things tha…
"I think it is probably a lot more complicated than that." That's an evergreen, accurate response to anything in human biology!
So you're saying I'm right! ;-)