Josh from Let's Encrypt here. First, my apologies for the trouble this has caused. I want to offer people here an early root cause analysis. I say early because we have not entirely completed our investigation or a post-mortem. OCSP requests that use the GET method use standard base64 encoding, which can contain two slashes one after another. While debugging why a small number of OCSP requests consistently failed our…
They are quite important for www-stuff you know.
"a majority of the OCSP requests we were receiving were prepended with a slash"
Everything is unsafe - one has to make sure that external data is converted into a sane format internally; and to never assume that external input can be safe!