Django is not meant to be run at scale. At least not horizontal scale. If you're not going to use the ORM, which prevents you from scaling horizontally, why are you using Django? Django can be scaled by getting large instances with lots of RAM, which is quite affordable these days. It can also be scaled with caching. But if you want horizontal scaling, don't use Django. That's not what it's for.
There's nothing really inherent to Django that prevents it from scaling horizontally, not even the ORM. For the typical SQL read-heavy workload it will scale as well as anything else depending on the scalability of the backing RDBMS. Should always use proper HTTP response caching with something like Varnish or via 3rd-party CDN where possible.
As far as I know, none of the backing RDBMSs that the ORM supports are horizontally distributable. At least not officially, right? CockroachDB with its Postgres interface sounds good, or Citus? But as of today, are any of the supported DBs distributed?