React popularity seems to me the result of wrongly-headed thinking: that because facebook is popular, any technology behind it must be good, and because react is popular (allegedly), react must be good. I've always been very sceptical of react, and I'm glad I didn't invest too much time looking into it, as it seems both a time sink and a boilerplate-filled approach. I wonder why some people like it, writing no-framew…
I am not a js dev, but isn't the issue of no-framework that you have to write a bunch of code to deal for various browsers? And a bunch of more code to deal with basic web patterns that you'll end up copying from project to project?
For me, jQuery is the bare minimum requirement. I would never attempt to write a large app in pure JS, even with babel. You would definitely run into some of the problems you mentioned.
EDIT: I see now where he mentioned no-framework JS