As a Googler, I could relate countless stories of systems that were cobbled together in Python and then scaled up with massive investment, then later rewritten in C++ or Go, and generally ran with 100x fewer resources. Hell, from what I can tell, almost all of YouTube was written in Python and has or is still being rewritten in C++, Java, and Go, saving XX millions of dollars per year of CPU time.
Sure, prototype with Python. But by the time you get to scaling out a huge service, it's probably time that you rearchitected the system anyway, and you should spend the engineering effort to make it efficient.