Would he have made those same comments to resist going from 16 to 32 bit? Hell, why not stick with 8 bit? We can just optimize everything to work on that, right?
In a 16-bit address space (64K), you hit the 16-bit limit _all the time_. Even a moderately sized text document will be bigger than 64K... and that's before considering images, videos, large data sets, etc.
32-bit takes you out to 4GB, which is much more likely to hold a typical working set, so the argument to go to 64-bit is much less pressing.
"why not stick with 8 bit?"
This conversation is about the size of the address space, not the machine word size. To my knowledge, there were no serious machines of any sort that were limited to an 8-bit address space. (Maybe something homebrew or embedded.) The closest I can think of is the 6502's preference for putting values in the zero page (which was 256 bytes).