Earlier quoted context omitted.
In-memory doesn't imply "unreliable". If you need high-availability you'll want to use replication anyway.
In-memory with periodic snapshots sure implies "not durable," though. (That is, you will lose whatever data has not yet been snapshotted on a power failure or crash.) Replication doesn't fix that, unless you're willing to impose the latency of replication to different datacenters for each update. (I don't think Volt even supports this. Most systems don't.)
Future versions of VoltDB will do more address this single-data-center catastrophe scenario.