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Eating less and more than needed on alternate days prolongs life (2006)

ncbi.nlm.nih.gov

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Re: Eating less and more than needed on alternate days prolongs life (2006)

#6

Post by reasonattlm »

Slows glaucoma: https://dx.doi.org/10.1038/srep33950

Effects in long-lived mice: https://doi.org/10.1016/j.exger.2013.06.009

Protective of the aging heart: https://doi.org/10.1016/j.freeradbiomed.2009.10.003

Benefits without calorie reduction: https://dx.doi.org/10.1073/pnas.1035720100

In nematodes, looking at signaling: http://dx.doi.org/10.1038/nature07583

And so on. There is a lot more out there on this topic:

https://www.ncbi.nlm.nih.gov/pubmed/?term=alternate+day+fast...

Researchers still have a very long way to go in order to understand the calorie restriction and intermittent fasting responses completely. In order to do that one pretty much as to have a complete map of cellular biochemistry. Don't hold your breath waiting for that to happen; decades is a very reasonable expectation, I think, based on watching progress in understanding sirtuins over more than a decade, which is just one very thin slice of a very large problem. Practical rejuvenation based on repair of damage after the SENS vision (such as via clearing senescent cells) will be a going concern well before researchers can fully explain calorie restriction in the context of age-related changes and cause and effect in the operation of mammalian biochemistry.

Re: Eating less and more than needed on alternate days prolongs life (2006)

#7

Post by rubicon33 »

I have long believed, due entirely to anecdotal evidence, that restricting calories and eating less is one of the best ways to add years to your life. It seems that eating is inherently stressful for the body. Though obviously necessary, eating is something that we should strive to minimize. Any more than necessary, and the stress induced from digestion, and inflammatory molecules, damages the body and undermines our ability to fight infection.

Re: Eating less and more than needed on alternate days prolongs life (2006)

#9

Post by jackvalentine »

zeamaize wrote: post #5

This sort of result has been showed repeatedly. We really need more (and better) nutrition education. The level of obesity and overeating in our society is astounding. I'd be surprised if most people could even implement basic calorie counting.

Having tried implementing calorie counting... how exactly do you do it?

You either cook everything yourself and weigh every ingredient. Or you buy totally packaged meals (Lite 'n Easy, etc), or you buy fast food (And even then, the calorie counts in fast food are... inaccurate at best).

If I go to the corner shop and get a sandwich I have no idea what's in it and there is no accurate way to estimate.

While it's good to be aware just how energy dense foods are (like muffins... aka breakfast cakes) there is no method that I'd consider both achievable for the average person to consistently do AND accurate enough to be considered 'counting' as opposed to washy estimates.

Re: Eating less and more than needed on alternate days prolongs life (2006)

#10

Post by vannevar »

This seems flaky:

"Since May 2003 we have experimented with alternate day calorie restriction, one day consuming 20-50% of estimated daily caloric requirement and the next day ad lib eating, and have observed health benefits starting in as little as two weeks, in insulin resistance, asthma, seasonal allergies, infectious diseases of viral, bacterial and fungal origin (viral URI, recurrent bacterial tonsillitis, chronic sinusitis, periodontal disease), autoimmune disorder (rheumatoid arthritis), osteoarthritis, symptoms due to CNS inflammatory lesions (Tourette's, Meniere's) cardiac arrhythmias (PVCs, atrial fibrillation), menopause related hot flashes." (Emphasis mine.)

Are they still talking about mice? Or experiments on people?

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