I have the opposite question for people here: what drives you to more money? A very expensive house costs a few million dollars, which you should afford quite easily, especially if you have a partner making a decent amount of money. Children and their education cost quite a bit in the US, but even that shouldn't cost a lot. A few expensive holidays per year plus retirement money should be easily doable. So, basically…
So a down payment would likely be $300K-$600K.
Let's say $400K income.
NerdWallet says that even at $600K down with under $2K of monthly obligations, you're still "stretching" to get to $2.25M, so "afford quite easily" seems a bit questionable.