Live data from Hacker News

Why Is Cancer More Common in Men?

harvardmagazine.com

91–100 of 107 posts

Re: Why Is Cancer More Common in Men?

#91
post #77

Earlier quoted context omitted.

It does not contradict my statement. If they are less likely to seek medical treatment, they receive worse medical treatment (or no treatment at all).

Worse and less are two different things. One is a judgement of quality, the other a judgement of quantity.

Except when they're both required and neither is sufficient, as in this case. In preventative medicine, in order to have quality one must have quantity.

Re: Why Is Cancer More Common in Men?

#92
post #47

Hypothesis: it's socially more acceptable for men to not care for their body as much as women do, eat worse, drink more soda and beer, etc. leading overall to more sugar(y) foods and more inflammation?

Social anecdotal evidence from the United States: according to TV commercials the most pressing female health problem is breast cancer, while the most pressing male health problem is Erectile dysfunction.

Re: Why Is Cancer More Common in Men?

#93
post #53

So is the second X chromosome in women supposed to be an exact copy of the first or do they differ? That's fascinating to me all by itself, and more so that some genes in the dupe can reinforce the first even though the rest of the chromosome is suppressed. EDIT: Ah, wikipedia explains that the two X chromosomes in a standard-issue woman come from the mother and paternal grandmother, and then ... "Early in embryonic…

> Being a male, I'm troubled by the fitness of the Y-chromosome over the generations. It seems to me that it can only accumulate errors and mutations. In fact, the Y-chromosome has completely disappeared in some species [0]. [0] https://en.wikipedia.org/wiki/Y_chromosome#Future_evolution

Fascinating, did not know that "loss of Y" was possible in vivo, not just evolutionarily across spans of generations. This led me to finding out that loss of Y is tentatively tied to Alzheimer's, and wondering if chronically low testosterone levels are possibly linked to loss of Y.

Re: Why Is Cancer More Common in Men?

#94

More money is spent on preventing cancer in women in treatment, research, and preventive medicine. Google the history of the brca gene, research and tests around it. Its quite amazing.I hope all cancer research gets the pipeline it got.

If this is talking about a prostate vs breath cancer dichotomy. The reason is prostate cancer kills much older men than breast cancer kills women. Women in their 40s routinely die of breast cancer but that's pretty rare for a man in his 40s to die of prostate cancer. So saving a man's live fron prostate cancer means he dies at 75 instead of 70 and but saving a women's from breast cancer means she dies at 65 instead o…

By this reasoning children's diseases should get even more publicity and money, and I'm aware of nothing in that area that comes even remotely close in terms of funding and awareness campaigns.

Re: Why Is Cancer More Common in Men?

#95

So is the second X chromosome in women supposed to be an exact copy of the first or do they differ? That's fascinating to me all by itself, and more so that some genes in the dupe can reinforce the first even though the rest of the chromosome is suppressed. EDIT: Ah, wikipedia explains that the two X chromosomes in a standard-issue woman come from the mother and paternal grandmother, and then ... "Early in embryonic…

Um the X chromosome in a women comes from the mother and the paternal grandmother and grandfather because there is crossover between X and Y chromosomes (albeit very little).

There's no need to worry about the Y chromosome disappearing because it's remarkably stable. This makes sense -- males with Y mutations die out and men are extremely good at producing offspring. This only good Y chromosomes are passed on.

Nevertheless, the genes on the Y chromosome are like any other and if the Y chromosome were to disappear, natural selection would still push for a 50/50 sex ratio. The Y chromosome itself isn't necessary to make a male -- its genes can be spliced onto the X chromosome and function properly. Thus, if we saw loss of Y, we would likely see a 50/50 gender split but now based on presence of the SRY gene.

Re: Why Is Cancer More Common in Men?

#96

More money is spent on preventing cancer in women in treatment, research, and preventive medicine. Google the history of the brca gene, research and tests around it. Its quite amazing.I hope all cancer research gets the pipeline it got.

The breast cancer movement was started because at the time, male-only cancers (such as prostate and testicular cancers) were getting far more funding and research, while breast cancer was essentially being ignored despite being at least an order of magnitude more common. That it's more common has probably made it easier to do research on once it gained sufficient visibility and funding.

And yet we still have no treatment for testicular cancer other than castration -- so much for all the research.

Re: Why Is Cancer More Common in Men?

#97
post #47

Hypothesis: it's socially more acceptable for men to not care for their body as much as women do, eat worse, drink more soda and beer, etc. leading overall to more sugar(y) foods and more inflammation?

Also, men don't get multiple periods in their lives when they are checked out for every condition under the sun. My wife's health was given a thorough run down when she was pregnant and a bunch of things caught and fixed -- like her hypothyroidism. I go regularly to my physicals and had never been checked out so much.

I ended up demanding that I too get tested for some of these things, and the doctors caught that I also had an asymptomstic but more serious autoimmune thyroid disease. Had I been a woman, I would have caught this during pregnancy check ups, and been treated. Instead I had to demand it.

Now of course I think it's fine for pregnant women to be given priority but we need to realize that men don't get the equivalent treatment and thus encourage programs to get men in to the doctors, thoroughly tested, and treated. Make it part of a pre-birth check up for fathers. After all, once the baby is born, it would be nice if they had a father.

Re: Why Is Cancer More Common in Men?

#98
post #9

Because men receive worse medical treatment. Just compare how prostate and breast cancer are promoted. It also corresponds with other statistics like life expectancy, medical expenses, disposable income...

On the flip side, studies have shown that women are less likely to be taken seriously when bringing a medical concern or complaint to a doctor. Which might suggest that women are under-diagnosed compared to men.

Recall a study done on psychologists (think it was done in Sweden).

Men were significant less likely to be taken serious and admitted. However those few who are admitted are then taken more serious, and get more direct treatment than women. From a cultural perspective, men are viewed as always healthy, and in the exceptional case where its proven false then they are expected to be restored back to the norm. Women get the opposite cultural treatment, where they are easy accepted as sick but then the health system gives up and don't expect them to be able to be restored back.

Re: Why Is Cancer More Common in Men?

#99
post #47

Hypothesis: it's socially more acceptable for men to not care for their body as much as women do, eat worse, drink more soda and beer, etc. leading overall to more sugar(y) foods and more inflammation?

I think its more that society impose pressure on women to care how they look and being healthy, while imposing similar requirement on men to care about their ability to raise money. Dating site statistics shows a very strong correlation for successful profiles that follows those gender roles, where a man who focus more on about taking care of their body than their carer has a negative correlation, and women who focus more on their carer than taking care of their body has a negative correlation.

Genetic differences between males and females may account for some of the imbalance in how often people get sick, but incentives may also account for some. The article don't really explore that.

Re: Why Is Cancer More Common in Men?

#100
post #82

So is the second X chromosome in women supposed to be an exact copy of the first or do they differ? That's fascinating to me all by itself, and more so that some genes in the dupe can reinforce the first even though the rest of the chromosome is suppressed. EDIT: Ah, wikipedia explains that the two X chromosomes in a standard-issue woman come from the mother and paternal grandmother, and then ... "Early in embryonic…

It's worth pointing out that since Barr body deactivation occurs later in development, some female cells have one of the X chromosomes active, while other cells have the other one active.

So is it wrongheaded to think all women are a bit of a chimera, then? It would seem females would benefit for the most part from this chromosomal arrangement healthwise than males, more diversity.
Post reply on HN