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US government to withdraw longstanding warnings about cholesterol (2015)

washingtonpost.com

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Re: US government to withdraw longstanding warnings about cholesterol (2015)

#211
post #98
post #54

Earlier quoted context omitted.

Just as an example: 9% of the cases of Idiosyncratic Drug-induced Liver Injury is self-harm caused by people taking non-regulated dietary supplements: https://www.ncbi.nlm.nih.gov/pubmed/18955056 You have a theory that the average person will wisely assume the responsibility to vet the health effects of what they consume, but empirical reality disagrees with your theory. Right now people are injuring themselves with…

Idiosyncratic Drug-induced Liver Injury (DILI) is only 13-20% of all DILI. The other ~80% being pharmacological. About 40% of all acute liver failure is caused by acetaminophen. http://www.nature.com/ajg/journal/v102/n11/full/ajg2007481a.... Meaning a single FDA approved over-the-counter drug is responsible for over 20 times as much liver failure as all dietary supplements. Some regulation may be beneficial but the c…

Acetaminophen is a interesting example - it's a very (centuries) old drug that predates the regulatory framework we have today. Some scholars (see ref. 1 for some history) suggest that it would not be approved by today's FDA.

It's thus a poor selection if one wishes to discredit the FDA's efficacy; indeed, some other widely-used therapeutics (e.g., aspirin) came into use before drug efficacy was required for new drug approval.

At the same time, there are numerous examples of drugs either not approved by the FDA or withdrawn from the US market by the FDA. It's not clear how less regulation would achieve this type of nation-wide safety benefit.

[1] http://s3.documentcloud.org/documents/793731/mcneil-history-...

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#212
post #111
post #54

Earlier quoted context omitted.

Just as an example: 9% of the cases of Idiosyncratic Drug-induced Liver Injury is self-harm caused by people taking non-regulated dietary supplements: https://www.ncbi.nlm.nih.gov/pubmed/18955056 You have a theory that the average person will wisely assume the responsibility to vet the health effects of what they consume, but empirical reality disagrees with your theory. Right now people are injuring themselves with…

You didn't show any evidence of the FDA being a net benefit. You only showed that the FDA probably could have reduced that specific type of liver injury by regulating those specific supplements. But the government is not magic, and the FDA almost certainly has also caused injuries by overly or erroneously regulating other things. I have no idea what the net effect is, but you certainly haven't shown it to be positive…

I'm curious about your assertion of 'overly' regulating things leading to a net negative effect. Are there specific examples you're considering?

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#213

Wouldn't it be nice if there were more government warnings and less restrictions / regulations? Imagine if the FDA, instead of blocking new drugs for 10 years and $1B, it simply withheld its endorsement until satisfied by the clinical trials. Consumers could then take the government's recommendations into consideration when making a decision and drugs could get to market much faster. The history of medical reversals…

Govt everywhere : "Don't be obese"

Result: highest rate of obesity in history

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#214
post #194

Earlier quoted context omitted.

And people will also choose to eat potato chips, not exercise, smoke, and drink heavily. You can't protect people from themselves, and even if it was an ethical government job to do so, i.e. take away people's freedoms because the government says it knows better, like with marijuana (I am REALLY humoring you, if you can't tell), there is no practical argument either. How much do you think your high estimate of X% who…

> You can't protect people from themselves You can't protect all people from themselves, but you can protect a lot of people from themselves. If you look at smoking [1] in the US, smoking went from 42.4% in 1965 to 16.8% in 2014. Raising awareness, taxing cigarettes, outlawing advertising, warnings on packaging, these things work. The same could be done with alcohol if society wanted. One of the reasons why it hasn't…

Oddly, the people you're asking to implement this harm reduction plan are often making the same mistakes as those who would "benefit" from the regulations.

Government bureaucrats are not special or different from us regular folk. Why should we expect them to be?

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#215

Earlier quoted context omitted.

> The problem with this is that the average consumer is both A) dumb, and B) doesn't know what they need Note that the customer for prescription drugs is a licensed doctor.

> Note that the customer for prescription drugs is a licensed doctor. Who can be bought and misled like anyone else.

Just like federal regulators can be bought and misled like anyone else.

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#216
post #97

This doesn't go far enough. That there is a link between high cholesterol and heart disease is only a hypotheses, not a scientifically proven fact. Lowering cholesterol does not necessarily lower heart disease. Read more here: http://www.nytimes.com/2008/01/27/opinion/27taubes.html Because the link between excessive LDL cholesterol and cardiovascular disease has been so widely accepted, the Food and Drug Administrati…

Your comment reminds me of a thread I read in the Primal Diet's forum. http://www.marksdailyapple.com/forum/forum/the-primal-bluepr... Quite a few of them are having heart attacks: "So my first heart attack, 8 years after a stroke, was unexpected. My heart is determined to kill me. I've had at least 4 attacks, the last one keeping me in hospital 6 days" Yet they still all stay on that diet, because of some convincing…

That thread is fucking scary.

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#217

Earlier quoted context omitted.

Your comment reminds me of a thread I read in the Primal Diet's forum. http://www.marksdailyapple.com/forum/forum/the-primal-bluepr... Quite a few of them are having heart attacks: "So my first heart attack, 8 years after a stroke, was unexpected. My heart is determined to kill me. I've had at least 4 attacks, the last one keeping me in hospital 6 days" Yet they still all stay on that diet, because of some convincing…

That thread is fucking scary.

It's about equal to doctors telling me to eat low sat fat and low cholesterol in 2016. The difference is doctors went to school for this and still are wrong.

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#218

Earlier quoted context omitted.

I agree with you. This article also mentions they're focusing on fats/saturated fats; which is also a terrible focus. The real danger is not fat, even saturated/trans-fats, but starches and sugar. The increase in these types of carbohydrates in products like baby formula is actually leading to obesity in infants! Excess sugar can stress arteries and damage them. Cholesterol is carried to these artier by lipids (LDLs…

It's also a myth that runners need a high carb diet. I was a competitive distance runner for many years with a high carb diet and I'm confident that my performance suffered because of it. You're cells become much more efficient at using energy as you train, so you really don't need to eat that many calories at all. I was running 80+ miles per week, with a not above average calorie intake (for Americans), and my weigh…

The average American probably eats 60-70% carbs.

They would do well on more like 25% carbs aka Paleo.

As a distance runner, I don't perform well at 25% carbs. I need more like 40% carbs. So not "high carb", but "higher carb then a sedentary person needs".

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#219
For those who are curious, the 2015-2020 Dietary Guidelines is available here https://health.gov/dietaryguidelines/2015/resources/2015-202... (PDF)

Unfortunately it does not highlight the danger of sugar & processed food. Someone can follows these dietary guidelines and still be able to have a high intake of sugar, HCFS, processed food and all sorts of food chemicals (emulsifiers etc.), all prevalent in the american food industry, and get cardiovascular disease.

We are not going to reverse the obesity epidemic anytime soon!

Re: US government to withdraw longstanding warnings about cholesterol (2015)

#220

Earlier quoted context omitted.

That thread is fucking scary.

It's about equal to doctors telling me to eat low sat fat and low cholesterol in 2016. The difference is doctors went to school for this and still are wrong.

Except it's not.

The reason we have these publications is that medicine is continually reevaluating its recommendations. Your statement is about as unreasonable as saying 'we don't need computers since sometimes computers stop working'.

Also, if you've ever spoken to a doctor about this, few would disagree that nutrition is an area where we still need more research.

Finally, ask yourself: in the absence of evidence, is a diet that avoids fats/cholesterol (which, a priori, are associated with heart vessel disease[1]) such a silly idea? Now, we know more, and are changing recommendations accordingly.

1. https://www.nhlbi.nih.gov/health/health-topics/topics/athero...

1b. (in case you don't trust a governmental source) https://en.wikipedia.org/wiki/Atherosclerosis

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