It depends on what you want to optimize for. If you're starting a startup and you anticipate having a dedicated design team, I think you're better off making your markup match your domain and hand-rolling the CSS instead of using a framework like Bootstrap. This is the ideal approach IMO because it lets you much more effectively keep the styling out of the markup and in the stylesheets. CSS frameworks by definition r…
How do mixin-based CSS frameworks require you to put styling in your markup?