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Withdrawal from Antidepressants

madinamerica.com

31–40 of 131 posts

Re: Withdrawal from Antidepressants

#31
post #2

On a related note, there's no good half-life calculator on the web for people tapering off SSRIs. The issue is that in order to actually have as gentle a taper as possible, you need to halve your dose only every few weeks because of how long the half life of these drugs is. So ideally you'd want something where you would enter your starting dose and how much of the drug you plan on taking each day, and it would show…

> The issue is that in order to actually have as gentle a taper as possible, you need to halve your dose only every few weeks because of how long the half life of these drugs is.

The meds with worst discontinuation effects are those with short half life. Those with longer half life tend to have gentler discontinuation effects.

EG https://www.ncbi.nlm.nih.gov/pubmed/10855379/

> Serotonin re-uptake inhibitor withdrawal syndrome generally begins within 24 to 48 hours after discontinuing the drug. Signs reach their maximum on day 5 and usually resolve within 2 to 3 weeks. Withdrawal syndrome is more common with short half-life drugs (paroxetine, fluvoxamine). The intensity of the clinical signs depends on the daily dose and how long the drug has been given.

Re: Withdrawal from Antidepressants

#32

As someone who had to abruptly come off venlafaxine due to side effects, I can tell you that it was complete hell. I experienced vomiting, the weirdest, most horrible nightmares every night, sleep paralysis with hallucinations and a recurring feeling of "electic shocks" inside my head. This lasted about a month. I think it borders on inhumane not to mention possible withdrawal symptoms before prescribing this awful "…

I'm curious... you, and all other commenters who mentioned electric shocks... which I'd previously heard of as "brain zaps"...

What difference would it make if the doctor had told you of that side effect before you started the drug? Imagine you have no idea of what brain zaps felt like. Would you have avoided the drug based on such a vague description?

Can you describe the sensation? It's not painful, right? The sensation of an electric shock is sensory nerve input driven by external electricity, but there are no sensory nerves in the brain are there? So it's confusing to me (never been on psych drugs, so never gone through psych drug withdrawal) what these brain electric shocks could possibly feel like.

I assume you can't localize the sensations to somewhere that has nerves, like maybe the eyes, or somewhere—anywhere—else that really does have nerves? So it's like re-balancing the synapses after quitting these drugs causes a phenomenon in the somatosensory cortex that simulates non-localized zap sensations in a place there are no sensory nerves? Is it limited to a sensation, or are other senses (vision, hearing, smell, taste) ever involved? Is it perhaps more like a non-physical zap that's more like an interruption or glitch in consciousness than a ghost physical sensation?

[edit] So one person's experience with one day off meds was a feeling of floating or vague floating-like feeling of imbalance. That's probably related, perhaps an earlier stage of the phenomenon, but doesn't sound quite the same as the electric shocks people mention they get after quitting. Are the electric shock feelings anything like a rapid (instantaneous?) change in balance, like a shift to zero-g and back?

Re: Withdrawal from Antidepressants

#33

I have been on paxil(paroxetine) three separate times. Each was between six months and one year in duration. The first time, I was on a 10mg daily dose. I had quite a few issues when starting the medication the first time; however after a few weeks, I felt great. When I initially discontinued, I had the worst side effects I have ever experienced. Electric shocks in my neck and back of head, depression, mood swings, a…

Good to know, I had to take paroxetine for cripping anxiety, and will probably attempt end of treatment in a month.

I remember being off one day (10mg per day) and having the same sensation you get when an elevator stops after going up. A chill in your spine, except it was very intense, and located in my brain only. Lasted a day, only thing that would relieve it is swallowing something..

I really hope I don't have to enjoy this kind of black magic again next month. I'll be sure to go off very smoothly.

Re: Withdrawal from Antidepressants

#34
post #28

I have been on paxil(paroxetine) three separate times. Each was between six months and one year in duration. The first time, I was on a 10mg daily dose. I had quite a few issues when starting the medication the first time; however after a few weeks, I felt great. When I initially discontinued, I had the worst side effects I have ever experienced. Electric shocks in my neck and back of head, depression, mood swings, a…

Doctors can be notoriously ignorant and contradictory when it comes to mental illness-treating drugs. There's a lot of literature out there and a lot of them don't keep up. I don't know why it is. Not that you shouldn't trust doctors, but I always do some Googling to get a second opinion about all psychoactive drugs I'm prescribed.

It's very very uneasy when doctors are too handwavey on your issues. You don't know if they're skipping beats because they don't want to explain 10 years of med school so you obey, or if they just don't want to investigate more than what the usual answer is.

I tried to nitpick on things that mattered for me, but you cannot easily claim "I'm more up to date than you on illness" to a legal doctor without feeling a little ridiculous.

That's why I root for more non invasive monitoring and intervention. Many doctors told me the "based on these tests, you have nothing", bailing out when I asked for more because deeper tests would require potential ICU. So you end up floating in the unknown hoping for the best.

Re: Withdrawal from Antidepressants

#35

As someone who had to abruptly come off venlafaxine due to side effects, I can tell you that it was complete hell. I experienced vomiting, the weirdest, most horrible nightmares every night, sleep paralysis with hallucinations and a recurring feeling of "electic shocks" inside my head. This lasted about a month. I think it borders on inhumane not to mention possible withdrawal symptoms before prescribing this awful "…

I'm not off meds but since two weeks I had quite strange nightmares. A weird blend of terror and non daily event based (having nightmares after being mugged wouldn't scare me more than that). Waking up in sweat, heart racing and still not sure what reality I was in.

Re: Withdrawal from Antidepressants

#36
I had this terrible experience before I was publicly out about my gender that sent me into a very suicidal train of thought. I had a moment clarity to get myself to a doctor (my partner was pregnant at the time, or I probably won't be here writing this now).

The doctor gave me citalopram (brand name is Celexa, I think?) I had to stop taking it. I'll list the side effects I had, but not before I point out: It saved my life. Yes, I had bad side effects. But it also helped me overcome the anxiety and rage I was suffering from and resolve to come out about my status.

Ultimately I had to taper off of it, which was hard. My doctor advised reducing my dose by 1/4 the original value every 9 days until I was done. The end of it was quite rough, I confess.

But while on it, I gained nearly all the weight I lost in a year of physical training back (just 4 months of treatment), my heart palpitations were nauseatingly bad, and I suddenly had to sleep a lot longer to get even a modicum of rest.

When people say, "You should consider medication" it is to help normalize the idea that in trauma situations medication can help people with some types of MI. It is not because they're fun, side-effect free, or not a "real" course of treatment. It's important to remember that when considering these stories and your own mental health.

Re: Withdrawal from Antidepressants

#37

As someone who had to abruptly come off venlafaxine due to side effects, I can tell you that it was complete hell. I experienced vomiting, the weirdest, most horrible nightmares every night, sleep paralysis with hallucinations and a recurring feeling of "electic shocks" inside my head. This lasted about a month. I think it borders on inhumane not to mention possible withdrawal symptoms before prescribing this awful "…

I'm curious... you, and all other commenters who mentioned electric shocks... which I'd previously heard of as "brain zaps"... What difference would it make if the doctor had told you of that side effect before you started the drug? Imagine you have no idea of what brain zaps felt like. Would you have avoided the drug based on such a vague description? Can you describe the sensation? It's not painful, right? The sens…

Your comment got me curious. I mentioned weird sensations above: https://news.ycombinator.com/item?id=13224947

Never heard of brain zaps, my issues were more like a constant fuzz in the back of my head (felt like constantly falling in zero G)

Re: Withdrawal from Antidepressants

#38

I had this terrible experience before I was publicly out about my gender that sent me into a very suicidal train of thought. I had a moment clarity to get myself to a doctor (my partner was pregnant at the time, or I probably won't be here writing this now). The doctor gave me citalopram (brand name is Celexa, I think?) I had to stop taking it. I'll list the side effects I had, but not before I point out: It saved my…

Did the side effects from Celexa correspond to those found on this health search engine Healthbee

Re: Withdrawal from Antidepressants

#39

I had this terrible experience before I was publicly out about my gender that sent me into a very suicidal train of thought. I had a moment clarity to get myself to a doctor (my partner was pregnant at the time, or I probably won't be here writing this now). The doctor gave me citalopram (brand name is Celexa, I think?) I had to stop taking it. I'll list the side effects I had, but not before I point out: It saved my…

I don't think even people like the anti-med Robert Whitaker would be against using these medications short-term, for major clinical depression or for other conditions where patients are low- or non-functioning; the primary goal there is to get people stable so they can participate in productive behavioral therapy or modification so that they don't need the meds long-term (particularly since afaik the balance of evidence is that the effectiveness of these meds declines to the placebo level over the long term). It's the use of psychiatric medication for relatively minor psychiatric disturbances in high-functioning individuals, and for long periods of time (years), that draws most of the criticism.

Re: Withdrawal from Antidepressants

#40

I have been on paxil(paroxetine) three separate times. Each was between six months and one year in duration. The first time, I was on a 10mg daily dose. I had quite a few issues when starting the medication the first time; however after a few weeks, I felt great. When I initially discontinued, I had the worst side effects I have ever experienced. Electric shocks in my neck and back of head, depression, mood swings, a…

I had a similar experience. I've only ever taken Paxil once, for maybe a month or so. Going into it, the only side-effect I experienced was an inability to climax during sex—-yeah, I know, too much information, but people need to know what they're getting into. When I stopped taking it, I experienced the same electric shock sensations you're talking about. My eyes twitched terribly, and I bounced back and forth between wanting to kill myself and wanting to kill everyone else. That lasted for around two weeks.

After that experience, I decided it was better to just feel depressed.

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