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Scientists engineer mice genomes to lengthen their lifespans by 30 percent

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Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#51
Summary of pro death arguments re: longevity progress

  Fairness
    Only rich people will get it. (no tech has ever done this.)
    Better to give money to the poor than science. (family,city,state,nation, has proven local investment beats foreign.)

  Bad for society
    Dead people make more room for new, other people. (consider going first.)
    Run out of resources (live people discover/extract/renew better than dead or nonexistant)
    Overpopulation (colonize the seas, solar system, or have a war.)
      Stop having kids
      Worse wars (nukes are more dangerous than having your first 220 year old person in 2136)
    Dictators never die (they die all the time and rarely of age)

  Bad for individual
    You'll get bored. (your memory isn't that good, or your boredom isn't age related)
    You'll have to watch your loved ones die. (so you prefer they watch you?)
    You'll live forever in a terrible state. (longevity requires robustness.)
    Against gods will (not if he disallows suicide, then it is required.)
More people make more progress faster. I'm glad my parents didn't decide the world would be prettier or work better without me in it. Einstein, Bell, Tesla, Da Vinci etc, still alive and productive would be nice. You're literally asking for others to die out of your fear. The burden should be higher. Have courage. If living longer sucks, we'll know 100 years from now, and decide then. First 220 year old in 2136 unless you know how to make one faster than 1 year per year? And that's if you added 120 years to a 100 year old person starting TODAY.

Man up, save your family, save yourself.

Disclaimer: I'm half way done with a book on this topic. Mail me if you're interested. Scivive on the most popular email service.

P.S. Curing aging isn't immortality. You die at 600 on average by accident, and if the parade of imaginary horribles comes true, even earlier.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#52
post #2

> The technique, which requires genetic engineering, cannot be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means. Still a ways off for human use but definitely interesting research.

Grow a new genetically engineered body from your stem cells then transplant your head.

Maybe wait and see if that Russian head transplant experiment is a success.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#53
post #18

tldr for biologists out there. They made a transgenic mouse line of doxycycline inducible Yamanaka factors in progeria (LAKI) background. Too high induction lead to mortality and teratomas, which is known. They cyclicly induced the Yamanaka factors and found it reversed signs of aging (prolong lifespan by ~30%)

Thanks so much. I don't know why news headline writers are so insistent on bullshit, when they could have taken a cue from you and said 'gene therapy increases mouse lifespans by 30%,' which would have been just as short and interesting but vastly more honest.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#54

Summary of pro death arguments re: longevity progress Fairness Only rich people will get it. (no tech has ever done this.) Better to give money to the poor than science. (family,city,state,nation, has proven local investment beats foreign.) Bad for society Dead people make more room for new, other people. (consider going first.) Run out of resources (live people discover/extract/renew better than dead or nonexistant)…

For you Sci-Fi fans out there, I highly recommend Kim Stanley Robinson's Mars trilogy. In his fictional world, humans do discover how to extend longevity and it goes into many of the social issues that arise (who gets treatments? The rich? The poor? How do we deal with over population?).

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#55

Summary of pro death arguments re: longevity progress Fairness Only rich people will get it. (no tech has ever done this.) Better to give money to the poor than science. (family,city,state,nation, has proven local investment beats foreign.) Bad for society Dead people make more room for new, other people. (consider going first.) Run out of resources (live people discover/extract/renew better than dead or nonexistant)…

> Only rich people will get it. (no tech has ever done this.)

Virtually every tech starts that way, though.

The societal upheaval of rich people getting smartphones a few years earlier is probably not something you can extrapolate to the societal upheaval from "you could live forever but you don't have enough money right now".

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#56
post #50

Its very noisy to read these 'blip' articles, rather like following the stock ticker blow by blow ... Its wonderful that we see these interesting reports every week, but as a non-specialist you never how it will impact human longevity, and when. What I'd like to read is a well considered "state-of-longevity-science" report - by someone not Aubrey DeGray (give the man a medal) but equally cognizant, perhaps more conse…

I could put one together. Or you could read the last few years of posts at Fight Aging! and get the gist. But I'm pretty pro-SENS so it might not agree with your preferences.

The short answer to your question is that the impact of everything viable that is not SENS is probably going to be about the same as exercise or calorie restriction in your life span if you are in the middle of life now. Which is to say +10 years if you pick the right things, and the people building those things do a good job. That would be, say, the combination of a couple of successes in things building upon mTOR or stem cell or telomerase therapies or etc. Not resveratrol, not 99% of the other pharmaceuticals, not 99% of the possible gene therapies, and not 99% of what people are trying to sell you.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#57

Summary of pro death arguments re: longevity progress Fairness Only rich people will get it. (no tech has ever done this.) Better to give money to the poor than science. (family,city,state,nation, has proven local investment beats foreign.) Bad for society Dead people make more room for new, other people. (consider going first.) Run out of resources (live people discover/extract/renew better than dead or nonexistant)…

This is a bit of a straw man technique. You've framed the argument to suit your counterpoint.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#58

Summary of pro death arguments re: longevity progress Fairness Only rich people will get it. (no tech has ever done this.) Better to give money to the poor than science. (family,city,state,nation, has proven local investment beats foreign.) Bad for society Dead people make more room for new, other people. (consider going first.) Run out of resources (live people discover/extract/renew better than dead or nonexistant)…

  Fairness
   Only rich people will get it. (no tech has ever done this.)
Already, modern medicine expands lifetime and in particularly healthy lifetime significantly and the richer you are the more of it you can access.

Like, I don't have the same chances to get to 70 and still feel alright as someone born today in Bangladesh, or Zambia.

The world is already very unfair, and the only solution to that is to make it more fair, not to avoid developing treatments that, if the world was fair, would benfit everyone.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#59
post #50

Its very noisy to read these 'blip' articles, rather like following the stock ticker blow by blow ... Its wonderful that we see these interesting reports every week, but as a non-specialist you never how it will impact human longevity, and when. What I'd like to read is a well considered "state-of-longevity-science" report - by someone not Aubrey DeGray (give the man a medal) but equally cognizant, perhaps more conse…

To my knowledge no such report exists. The only answers you'll find will come from reading dozens of articles like this one over a long span of time, mixed with reading "primary sources" (put in quotes because as often as not those sources may be trying to sell you something).

While I am not qualified to put together a comprehensive report, I've been following this subject with some interest for a while, first as a skeptic, and now as someone who believes that not all of these people are completely full of hot air.

Even with my change of heart, I'd still bet against anything in your list other than crispr having any quantifiable impact on longevity in the next decade, and even then the first applications will be specific to particular age-related diseases.

Something resembling a more full "maintenance approach" to preventing aging and age-related disease may be within reach within 20 years, but I'd bet against that, too. Sticking my finger in the air and guessing, I'd say that such a complete overhaul of medicine is at least 50 years away. Although I should stipulate my guess is only that pessimistic because I'm biased towards thinking that such advances won't be made in my own lifetime because, hey, it rarely hurts to be a pessimist.

Re: Scientists engineer mice genomes to lengthen their lifespans by 30 percent

#60

Summary of pro death arguments re: longevity progress Fairness Only rich people will get it. (no tech has ever done this.) Better to give money to the poor than science. (family,city,state,nation, has proven local investment beats foreign.) Bad for society Dead people make more room for new, other people. (consider going first.) Run out of resources (live people discover/extract/renew better than dead or nonexistant)…

What fear is motivating me to ask other people to die, as you put it?

Eternal life would be sort of cool but I dispute your proposition that more people automatically make more progress faster. More people increases competition which incentivizes some kinds of progress but arguably retards others - consider our lamentable record of environmental destruction.

I don't think your aspirations are morally wrong in any way but your thesis seems unproven and I could just as easily argue that your efforts are primarily motivated by your own fear of death. Having had far more near-death experiences than most people I've met. I'm broadly OK with it because my experiences suggest to me that there's a lot more to consciousness than the everyday world, and that if and insofar as life has a purpose, it may be to reach some higher level of knowledge within finite constraints. I sometimes consider that life-as-we-know-it might be like some elaborated version of a book a film or a game (similar to but not the same as Bostrom's simulation argument).

Would you enjoy a book or a movie that never ended? Obviously there's a market for such things based on the continued existence of daytime TV soap operas, but nobody seems to think those shows have much cultural value.

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