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Parkinson’s disease ‘may start in gut’

bbc.co.uk

41–50 of 139 posts

Re: Parkinson’s disease ‘may start in gut’

#41
This is especially interesting, since coffee is moderately protective for Parkinson's.

Does that mean the coffee may be working at the gut level rather than its caffeine working in the brain? On second thought, coffee definitely works on the gut in normal people, if you know what I mean.

Re: Parkinson’s disease ‘may start in gut’

#42

Earlier quoted context omitted.

Short chain fatty acids can be things like acetic acid, propionic acid, butyric acid. The fermentation process takes in fiber and puts out these guys, so while fiber isn't an SCFA polymer, I don't think this statement is inaccurate (i.e. I don't have the metabolic pathways off hand but these could be direct breakdown products given the shortness of the carbon chains - acetic acid almost certainly is.)

I mostly agree. The main path for glucose involves splitting it in two 3 carbon molecules, mainly pyruvate https://en.wikipedia.org/wiki/Glycolysis From this it's easy to make acetic acid (2 carbons), like the acetic acid in vinegar. And , I guess it's also not very difficult to make propionic acid (3 carbons). I can accept that they say that fiber or glucose is "break down" to acetic acid, propionic acid, but I thin…

I think they're using it colloquially: you can "break down" trees in to paper, even though the paper technically requires reassembly and further processing from the most deconstructed tree step.

But it is a phrase that the average layperson would take as "simpler things made from the raw ingredients by the processors", rather than a direct deconstruction pathway.

It's a common problem when technical language collides with a common term or phrase, because most articles will mean the common one and send pendants in to a fit.

Re: Parkinson’s disease ‘may start in gut’

#43
post #37
post #8

What do we know so far? - Gut Bacteria are involved - Inflammation is involved - The brain works on glucose - The brain can also work on Ketones - Cinnamon seems to help in mice trials (and also has anti-inflammatory properties). - Could diabetes be analogous to Parkinson's? Diabetics generally have lost the ability to process carbs (usually by eating too many); could Parkinsons be caused by people being very dopamin…

Could diabetes be analogous to Parkinson's? Diabetics generally have lost the ability to process carbs (usually by eating too many); No. I'm assuming you are talking about type 2, which has nothing to do with the ability to process carbs but instead resistance to insulin. This is caused by so many different factors like genes, medications, stress, smoking, high intake of certain types of fats, lack of exercise, white…

Are you seriously arguing that eating excessively processed carbs and sugar doesn't lead to insulin resistance?

What about if I was to start injecting large amounts of insulin regularly?

Re: Parkinson’s disease ‘may start in gut’

#44
Has anyone noticed how quickly a new research direction gets connected to all the big diseases? It has only been a few years since microbiome research really became a thing. It is disconcertingly fad-like. From pubmed:

  pubmed - human microbiome	
  year	count
  2017	27
  2016	5464
  2015	5544
  2014	4283
  2013	2993
  2012	2064
  2011	1405
  2010	910
  2009	679
  2008	520
  2007	392
  2006	290
  2005	245
  2004	160
  2003	135
  2002	118
  2001	74
  2000	78
  1999	57
  1998	57
  1997	54
  1996	35
  1995	30
  1994	17
  1993	18
  1992	23
  1991	24
  1990	24
  1989	25
  1988	27
  1987	14
  1986	11
  1985	20
  1984	10
  1983	10
  1982	8
  1981	9
  1980	10
  1979	13
  1978	11
  1977	7
  1976	10
  1975	3
  1974	2
  1972	1
  1971	3
  1970	2
  1969	2
  1968	2
  1967	2
  1966	3
  1965	2
  1964	2
  1963	3
  1961	2
  1958	1
  1956	1

Re: Parkinson’s disease ‘may start in gut’

#45
post #8

What do we know so far? - Gut Bacteria are involved - Inflammation is involved - The brain works on glucose - The brain can also work on Ketones - Cinnamon seems to help in mice trials (and also has anti-inflammatory properties). - Could diabetes be analogous to Parkinson's? Diabetics generally have lost the ability to process carbs (usually by eating too many); could Parkinsons be caused by people being very dopamin…

I heard on NPR that common cold viruses are also some how related to the gut.

Re: Parkinson’s disease ‘may start in gut’

#46

My Dad was recently diagnosed. Very early stage. This is very interesting news. My take is that Parkinson's is a little like cancer in that it likely has multiple root causes that can injure the same part of the brain (substantia niagra) and cause the disease. My research for his case led me to vitamin k2 deficiency as a possible cause / complicating factor. There are some genetic models and mouse trials that show k2…

My father has Parkinson's and has severe osteoporosis, I wonder if there is a connection.

Re: Parkinson’s disease ‘may start in gut’

#47
post #37

Earlier quoted context omitted.

Could diabetes be analogous to Parkinson's? Diabetics generally have lost the ability to process carbs (usually by eating too many); No. I'm assuming you are talking about type 2, which has nothing to do with the ability to process carbs but instead resistance to insulin. This is caused by so many different factors like genes, medications, stress, smoking, high intake of certain types of fats, lack of exercise, white…

Are you seriously arguing that eating excessively processed carbs and sugar doesn't lead to insulin resistance? What about if I was to start injecting large amounts of insulin regularly?

Hes pointing out that what you said was factually incorrect. Diabetics don't lose the ability to process carbs at all.

Carbs are broken down along with proteins and fats. What Type 2 diabetes entails is glucose building up in the bloodstream with no real way to utilize it due to insulin resistance.

Re: Parkinson’s disease ‘may start in gut’

#48
post #44

Has anyone noticed how quickly a new research direction gets connected to all the big diseases? It has only been a few years since microbiome research really became a thing. It is disconcertingly fad-like. From pubmed: pubmed - human microbiome year count 2017 27 2016 5464 2015 5544 2014 4283 2013 2993 2012 2064 2011 1405 2010 910 2009 679 2008 520 2007 392 2006 290 2005 245 2004 160 2003 135 2002 118 2001 74 2000 78…

I know nothing about microbiome research. However, I don't think "fad-like" is a logical conclusion just because the amount of research is continuing to increase. This just seems more like typical human advancement and dissemination of knowledge.

For instance, I'm sure you'd find a similar trend with "computer", "solar energy" and "global warming". Someone discovers something and it takes a while for everyone to catch on. However, if the concept has legs, more and more research will take place until we understand the concept enough for it to become a part of every day life.

Re: Parkinson’s disease ‘may start in gut’

#49

Earlier quoted context omitted.

Are you seriously arguing that eating excessively processed carbs and sugar doesn't lead to insulin resistance? What about if I was to start injecting large amounts of insulin regularly?

Hes pointing out that what you said was factually incorrect. Diabetics don't lose the ability to process carbs at all. Carbs are broken down along with proteins and fats. What Type 2 diabetes entails is glucose building up in the bloodstream with no real way to utilize it due to insulin resistance.

Er... you are just assuming by process I mean digest.

To be clear:

> glucose building up in the bloodstream with no real way to utilize it

===

Inability to process carbs and sugar. Maybe your description is more accurate.

Re: Parkinson’s disease ‘may start in gut’

#50

Earlier quoted context omitted.

Hes pointing out that what you said was factually incorrect. Diabetics don't lose the ability to process carbs at all. Carbs are broken down along with proteins and fats. What Type 2 diabetes entails is glucose building up in the bloodstream with no real way to utilize it due to insulin resistance.

Er... you are just assuming by process I mean digest. To be clear: > glucose building up in the bloodstream with no real way to utilize it === Inability to process carbs and sugar. Maybe your description is more accurate.

Using the term "inability to process carbs and sugar" is misleading and totally not the same thing as insulin resistance.

Its generally assumed that processing carbs is the act of digestion. You're using the word processed in the wrong situation here.

EDIT: Also you can still process carbs, you just can't utilize glucose in the blood as a diabetic.

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