In the environment I'm in, my Linux home directory is shared by multiple systems. Most are CentOS 6, but we're starting to use CentOS 7, too. I'm using the default Gnome 2 Desktop on 6, but Mate Desktop on 7, as I don't like Gnome 3 or the "Classic" option. I can't point to any specifics at the moment, but I've had what I think are issues of these desktops stepping on each other. Being able to switch between DEs is n…
Centos6 will have different Gnome versions than Centos7. However, both will write in ~/.gnome, possibly .gtk, or .gtk-3.0 or wherever the hell they write to these days.
Better to share your data through an nfs share in /data instead of /home and take the pain of not having the exact Desktop across different nodes. Or to create a homogenous environment with only Centos7 for example.