We have a product that uses ipv6 for inter-server communications. We've since learned that most major corporations routinely disable ipv6 on every computer. Not helping.
My second-favorite problem, after that was solved, was developers constantly using IPv4-only code. Their eventual solution was to just disable IPv4 entirely so that anyone committing IPv4-only code was committing broken code.
It's amazing how much work it takes to bring people into the future.