My "road out" was having kids and taking on a lot of responsibility (both family and business). It's worked for 7 years now and I've never felt happier and mentally healthy, even if I am super busy and under a lot of pressure :-) I never thought I'd be the sort of person to thrive on pressure but it turns out I am.
I think many people do who don't realize it. There's a balance, certainly, and having a cause that you care about helps a great deal. Pressure from a job that just feels like a grind can leave you feeling stressed and unessential (why do we need yet another widget?!?). Pressure in supporting people you care about (family, friends), a country, a cause (ending hunger, eliminating a disease, etc.), and so on can leave y…
If you raise the stakes enough for almost anyone (or they are of a mindset to ratchet those stakes up for themselves) it can be paralyzing, unless the consequences of not making a decision are somehow worse.
In some ways, SV-style celebration of failure is great, but if you're fixated on a "Unicorn or Bust" (or even an "FU money or Bust") career path, well, having a few "busts" in a row (which is a fairly likely outcome, even if you have both a good idea and execution) might just kill you.
In this sense, choosing a cause to have a sense of purpose may be a terrible option for some folks to pursue, since the consequences of not solving it completely are still dire - eg. don't choose to work on solving the World Hunger Problem if, having eliminated 90% of the problem in five years, you are going to blame yourself for the less tractable remaining 10% that still die of malnutrition and hunger.