I have met some very competent musicians who have found 432 tuning to be powerfully effective. When I dug into this, I discovered they were tuning the other notes in the scal to frequencies in whole numbered cycles per second, using tables being passed around. So the real change was in the qualities of intervals ; many of these became far more resonant than the compromised resonant qualities we get with equal tempere…
If you're interested in this sort of thing, look for Wendy Carlos' album Switched-On Bach 2000. She revisits the material of her classic electronic music album with modern synthesizer equipment, and uses authentic Bach tunings for the pieces as well. The liner notes for the album explain the tuning systems used, and how they differ from the modern, mathematically-perfect equal temperament. She notes that Bach was him…
Tuning is just a block of data on a digital synthesizer, but on an analog synthesizer it's not. If you use a keyboard controller, it's generating pitch control voltages with a fixed 2^(1/12) ratio between notes (or logarithm thereof). It would be challenging to convert this into a just intonation.
On the other hand, if the pitch control voltages are generated by potentiometers on an analog sequencer [1] and the musician is setting those potentiometers by ear, the musician will probably end up tuning to a just intonation because it sounds more correct to the ear.