Earlier quoted context omitted.
The difference is mathematical, not physical, so it should still hold.
The mathematics depend heavily on physics. If physics outside of our universe differ - the math wouldn't add up. I can make 2 + 2 = 5 in a simulation. That doesn't mean 2 + 2 = 5 outside of the simulation.
I do not believe that to be true. While physics is heavily dependent on math, the reverse is not true.
> I can make 2 + 2 = 5 in a simulation.
No, I am fairly confident that you absolutely can not. You can make a simulation where putting 2 oranges in a box and adding two more oranges results in 5 oranges in the box (rather like putting together certain nucleons together into a nucleus results in a mass different than the sum of their individual masses). But in that simulation it would be a peculiar property of oranges, not a property of mathematics -- just as we don't claim addition is invalidated by the behavior of nucleon masses.