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A theory on how insulin resistance, metabolic disease begin

medicalxpress.com

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Re: A theory on how insulin resistance, metabolic disease begin

#41

Post by petra »

Declanomous wrote: post #37
petra wrote: post #35

Earlier quoted context omitted.

>> The actual problem is that less sugar enters the blood stream than is tasted. But tasted where ? do we have any knowledge what happens when the tongue measures one level of sweetness and the gut another ? And don't the case of the gastric bypass implies that if the gut senses less sugar(either because of less sensors, or because of less sugar) , we get positive results ? >> no substitute for eating healthy.. than…

The taste buds in your gut are on the same side of the gut as the food. So your gut can taste sugars that pass through you without being absorbed. Given that fact, we can speculate that sweet things that aren't absorbed might be more harmful than ones that are absorbed, as they have a chance to activate taste buds all the way through the gut as they go past, rather than just the earlier ones.

True, there might be such mechanisms.

Hopefully the guys at DouxMatok are think about this and optimizing their sweetener to quickly dissolve in the gut.

And sure, this definetly needs full animal testing before claiming things about it.

Re: A theory on how insulin resistance, metabolic disease begin

#42

Post by choicewords »

Declanomous wrote: post #16

My capstone project was actually about how sugar affects metabolism. There is a lot of interesting research and unexpected interactions in this area. One of the things that is most interesting is that they have found the same proteins that form our taste buds in the walls of our small intestine. It appears that the gut "tastes" food and "tells" the body what kind of food is coming and how to prepare for it. One of th…

Interesting. Any ideas on how the bacterial flora interacts with the sensing small intestines? Would they react as well when the sensation of sweetness goes over them?

Re: A theory on how insulin resistance, metabolic disease begin

#44

Post by e40 »

Declanomous wrote: post #16

My capstone project was actually about how sugar affects metabolism. There is a lot of interesting research and unexpected interactions in this area. One of the things that is most interesting is that they have found the same proteins that form our taste buds in the walls of our small intestine. It appears that the gut "tastes" food and "tells" the body what kind of food is coming and how to prepare for it. One of th…

Interesting. What do you think about sugarless gum? I chew it because it helps with my acid reflux. I'm wondering if it might cause a spike in insulin, like diet soda would.

I guess one good thing is I usually chew it after a meal, but I do occasionally chew on an empty stomach if I'm having trouble burping.

Re: A theory on how insulin resistance, metabolic disease begin

#45

Post by moosey »

jamroom wrote: post #40
phkahler wrote: post #32

>> If we can develop drugs to target this process, this may be a way to prevent the process early in the development of the disease Always gotta come up with a new drug. Why not just eat a diet with no added sugar?

There's no money in eating less sugar. These pharmaceutical companies are interested in one thing - making money, and therefore they need everyone to be a "customer" by taking one of their pills every day. This means even if there are simple (i.e. non patent-able) solutions to health problems, you won't see them pushing it - instead you'll see them ACTIVELY work to prevent it. A good example is the recent case where…

While I can agree that the blame for continued marijuana criminalization falls to some extent with pharma companies, I don't think that I can 100% agree with the sugar aspect.

If pharma develops a pill for this it's because people want to eat sugar. This will be the same for pills that eliminate hangovers (should they exist), why not just quit drinking?

Simple answer is that people want to do these things, and neither should be criminalized, nor should marijuana be criminalized. Eliminating the side-effects of these products will probably be dangerous (with even more side-effects, but different ones), but I guarantee that there will still be a market for them -- especially if people can eat and drink what they want and avoid obesity, even at the cost of other aspects of their health.

I really dislike pharma for attempting to continue criminalizing things like marijuana and kratom, but to apply the same logic to a pill that keeps people from gaining weight or avoiding diabetes while eating what they want is an entirely separate issue ethically and logically.

Re: A theory on how insulin resistance, metabolic disease begin

#47

Post by akiselev »

e40 wrote: post #44
Declanomous wrote: post #16

My capstone project was actually about how sugar affects metabolism. There is a lot of interesting research and unexpected interactions in this area. One of the things that is most interesting is that they have found the same proteins that form our taste buds in the walls of our small intestine. It appears that the gut "tastes" food and "tells" the body what kind of food is coming and how to prepare for it. One of th…

Interesting. What do you think about sugarless gum? I chew it because it helps with my acid reflux. I'm wondering if it might cause a spike in insulin, like diet soda would. I guess one good thing is I usually chew it after a meal, but I do occasionally chew on an empty stomach if I'm having trouble burping.

The amount of artificial sweetener in a can of diet soda is going to weigh an order of magnitude more than your one piece of gum (which is mostly made of an undisgestible polymer anyway, with very little in the way of actual flavorings). You might as well dissolve a packet of splenda in an eye dropper and take a few drops.

Re: A theory on how insulin resistance, metabolic disease begin

#48

Post by pixl97 »

__d__ wrote: post #46

What about people who eat high fruit and blame diabetes on fat intake? Can someone elaborate? These two individuals are crushing more than 30 fruits a day with high glycemic loads http://www.mangomannutrition.com/ http://mindfuldiabetic.com/coaching/

They are probably wrong about the fat causing problems...

That said, if they are eating raw, whole, fruits with most of their fiber intact (and from the look of their site, they are) they are reducing the glycemic index of the foods they eat.

Many processed foods are bad, not simply because they are processed, but that a massive amount of the fiber in the original food is removed. Fiber is a glycemic moderator, foods with high fibers have lower glycemic indexes. For example if you juice an orange, you've pretty much made kool-aid, it's junk food now. If you instead try to eat as many oranges in a glass of orange juice you would feel full before you finished and consumed a lower amount of calories because of that.

Re: A theory on how insulin resistance, metabolic disease begin

#49

Post by credit_guy »

akiselev wrote: post #47
e40 wrote: post #44

Earlier quoted context omitted.

Interesting. What do you think about sugarless gum? I chew it because it helps with my acid reflux. I'm wondering if it might cause a spike in insulin, like diet soda would. I guess one good thing is I usually chew it after a meal, but I do occasionally chew on an empty stomach if I'm having trouble burping.

The amount of artificial sweetener in a can of diet soda is going to weigh an order of magnitude more than your one piece of gum (which is mostly made of an undisgestible polymer anyway, with very little in the way of actual flavorings). You might as well dissolve a packet of splenda in an eye dropper and take a few drops.

I understand the GP's comment a bit differently. What matters is how much the taste buds are stimulated, not the amount of artificial sweeteners. If that is true, the sugarless chewing gum is many many times worse than the diet soda. The drink passes through your mouth in a few seconds, the gum stays in contact with your tong for half an hour (or more).

Re: A theory on how insulin resistance, metabolic disease begin

#50

Post by [deleted] »

akiselev wrote: post #47
e40 wrote: post #44

Earlier quoted context omitted.

Interesting. What do you think about sugarless gum? I chew it because it helps with my acid reflux. I'm wondering if it might cause a spike in insulin, like diet soda would. I guess one good thing is I usually chew it after a meal, but I do occasionally chew on an empty stomach if I'm having trouble burping.

The amount of artificial sweetener in a can of diet soda is going to weigh an order of magnitude more than your one piece of gum (which is mostly made of an undisgestible polymer anyway, with very little in the way of actual flavorings). You might as well dissolve a packet of splenda in an eye dropper and take a few drops.

[deleted]
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