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Chad Rigetti on Building Quantum Computers [video]

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Re: Chad Rigetti on Building Quantum Computers [video]

#2
The story of how Cray and his team created the CDC 6600 is really great [0]. Cray decided they had to get away from corporate interference so he picked a bucolic town a couple hours away from corporate HQ, moved his whole team there, and they worked in peace to develop a machine that was 10x faster than anything else.

It's unclear today if quantum computers will be useful, just as it was unclear in 1962 if supercomputers for large scientific numerical calculations would be useful. It'll be interesting to see.

[0] https://www.amazon.com/Supermen-Seymour-Technical-Wizards-Su...

Re: Chad Rigetti on Building Quantum Computers [video]

#6
post #5

His last bit reminds me of a quote I first heard on the West Wing: "Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it's the only thing that ever has." https://www.youtube.com/watch?v=43DOgo2VzGU

Genghis Khan: a small group of thoughtful, committed citizens. I like it.

Re: Chad Rigetti on Building Quantum Computers [video]

#7
I don't think quantum computing will have any sort of impact on drug discovery. Chad mentioned quantum computing's impact on drugs. Anybody know what he's referring to?

I haven't seen anything to suggest that there's big problems out there waiting to be solved by powerful computing capabilities. Has anyone else found something that suggests there's active problems waiting for quantum computers?

I've always found the missing thing in life saving pharmaceuticals is sick people to test compounds on.

Nonetheless, good to see YC pushing the envelope on impactful stuff.

I hope they desperately bring some inorganic and organic chemists with 10+ years of experience. It would open a new can of ventures that are meaningful. The good problems, the great ones, are in chemistry.

Re: Chad Rigetti on Building Quantum Computers [video]

#8
post #7

I don't think quantum computing will have any sort of impact on drug discovery. Chad mentioned quantum computing's impact on drugs. Anybody know what he's referring to? I haven't seen anything to suggest that there's big problems out there waiting to be solved by powerful computing capabilities. Has anyone else found something that suggests there's active problems waiting for quantum computers? I've always found the…

He means using computational chemistry to predict what different drugs might do without actually having to produce them one by one first. We are terrible at predicting how large molecules will act because they are complex quantum systems. So using a quantum computer to model them will hopefully be very successful.

Re: Chad Rigetti on Building Quantum Computers [video]

#9
post #7

I don't think quantum computing will have any sort of impact on drug discovery. Chad mentioned quantum computing's impact on drugs. Anybody know what he's referring to? I haven't seen anything to suggest that there's big problems out there waiting to be solved by powerful computing capabilities. Has anyone else found something that suggests there's active problems waiting for quantum computers? I've always found the…

> I don't think quantum computing will have any sort of impact on drug discovery.

I also was very surprised by that. I think it's probably 98% hype and 2% truth. There might be cases where the better understanding of physics brought by QC will impact a better understanding of biology. But I'd be very surprised if that made a big impact.

> I've always found the missing thing in life saving pharmaceuticals is sick people to test compounds on.

I don't think that's the case either. I think people who have a life-threatening illness are pretty willing to take part in trials. What I'd rather think is that likely the most important thing is to apply stricter scientific standards. Pharma companies have been complaining that they can't replicate the vast majority of pre-clinical cancer studies. The pharma companies themselves are also guilty of skewing research by hiding results and not sharing data. That's the thing that's holding up research. There's too much crappy science that wastes resources.

Re: Chad Rigetti on Building Quantum Computers [video]

#10
post #9
post #7

I don't think quantum computing will have any sort of impact on drug discovery. Chad mentioned quantum computing's impact on drugs. Anybody know what he's referring to? I haven't seen anything to suggest that there's big problems out there waiting to be solved by powerful computing capabilities. Has anyone else found something that suggests there's active problems waiting for quantum computers? I've always found the…

> I don't think quantum computing will have any sort of impact on drug discovery. I also was very surprised by that. I think it's probably 98% hype and 2% truth. There might be cases where the better understanding of physics brought by QC will impact a better understanding of biology. But I'd be very surprised if that made a big impact. > I've always found the missing thing in life saving pharmaceuticals is sick peop…

This is the case.

Finding someone with the perfect storm of conditions is really really tough.

The problem is that all the studies really have to be n=1 and the hunt for drug targets is now the hunt for the black swan.

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