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Can a molecule that makes mice smarter heal a human brain?

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Re: Can a molecule that makes mice smarter heal a human brain?

#3
post #2

I am curious. Does anyone know someone who has tried this on themselves yet?

Some "life extension" site forum had a group buy for the stuff apparently. People posted some of their results:

http://www.longecity.org/forum/topic/68589-isrib-group-buy-n...

One quote: So far I'm very much surprised about the effect on the overall cognition. My personal experiences are, that ISRIB definitely has it's effects on memory consolidation, but in my experience it doesn't only influence the long term memory formation (as JPC suggested), but the short term memory as well. It mens practicaly, that while reading a text, it is way much easier to remember the words, expression, and contexts as well (after 1-2 days). For instance currently I'm studying medicine basics again (I will enter a residency program soon), the subjects floaded with unique expressions related to molecular biology, basics of anatomy etc.. meaning, they are not very easy to link while memorizing even for a medical professional (they are meant to be boring..), and so far, after two days (meaning the text I read on friday) I can still remember a lot sharper on the names of for example cellular proteins, special basic physiological mechanisms than before, it is very obvious to me. I have to add, that I would value my memory above the average (as far as I can asses), but lately I somehow got slower by memorisation (I think it is an aging effect, and that was one of the reasons, why I started to search for some chemical hacking of my brain..).

Re: Can a molecule that makes mice smarter heal a human brain?

#4
post #2

I am curious. Does anyone know someone who has tried this on themselves yet?

One person claimed to have had it synthesized and taken it awhile back (linked from the article) http://www.longecity.org/forum/topic/68589-isrib-group-buy-n...

Re: Can a molecule that makes mice smarter heal a human brain?

#5
How does this now-patented "ISRIB" molecule compare to Leonard Guarente's research[1][2] on nicotinamide riboside and pterostilbene supplementation?

[1]: http://nymag.com/scienceofus/2016/08/is-elysium-healths-basi...

[2]: https://news.ycombinator.com/item?id=12345526

Re: Can a molecule that makes mice smarter heal a human brain?

#7
post #6

Isn't Flowers for Algernon required 7th-grade reading anymore? This isn't going to end well, people.

That was the first thing that leaped to mind for me as well, specifically the line, "P.S. please if you get a chanse put some flowrs on Algernons grave in the bak yard."

Kidding aside though, anytime the question of, "Does this thing in mice do this other thing in humans?" the answer is always, "Who the hell knows until after the study is complete?!"

Re: Can a molecule that makes mice smarter heal a human brain?

#8
post #2

I am curious. Does anyone know someone who has tried this on themselves yet?

Some "life extension" site forum had a group buy for the stuff apparently. People posted some of their results: http://www.longecity.org/forum/topic/68589-isrib-group-buy-n... One quote: So far I'm very much surprised about the effect on the overall cognition. My personal experiences are, that ISRIB definitely has it's effects on memory consolidation, but in my experience it doesn't only influence the long term memor…

Sample size of 1, no blinding, no verification of the substance received. Quite worthless.

Placebo effect is strong enough children recognised as more intelligent by chance do act and measure smarter.

Re: Can a molecule that makes mice smarter heal a human brain?

#10
post #2

I am curious. Does anyone know someone who has tried this on themselves yet?

One person claimed to have had it synthesized and taken it awhile back (linked from the article) http://www.longecity.org/forum/topic/68589-isrib-group-buy-n...

I see that you can buy it from Aldrich: http://www.sigmaaldrich.com/catalog/product/sigma/sml0843?la...
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