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The Age of the Superbug Is Here

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31–40 of 164 posts

Re: The Age of the Superbug Is Here

#31
post #29

Very naive question: won't bacteria lose their resistance after a while? What if we cycle certain antibiotics on an annual basis? When we reintroduce them, they'll be more powerful. Right?

I'm not sure, but that sounds like it might work. The real problem is: good luck getting all hospitals in the world to agree on a rotated schedule of which antibiotics to use / not use and when.

Re: The Age of the Superbug Is Here

#32
post #29

Very naive question: won't bacteria lose their resistance after a while? What if we cycle certain antibiotics on an annual basis? When we reintroduce them, they'll be more powerful. Right?

I was chatting to doctor friend recently who has a masters in this area and he said that in theory yes but it would likely require the bacteria to have a reason to loose the mutation that caused the resistance in the first place so there is no guarantee.

Re: The Age of the Superbug Is Here

#33
post #13

Earlier quoted context omitted.

I've been wearing contacts most of my life and have never heard said warning. Given pools are typically fairly sterile, I'm not sure if understand it. Now freshwater lakes or oceans under certain conditions I could understand

Swimming pools are far from sterile. The chlorine and other additives serve to inhibit the growth of organisms, but with so many contaminating bodies in it, they are far from sterile. Some public pools, not assiduously managed, at the end of the day, take on more than the aroma of chlorine; but even those that don't are not free of bacteria and other interesting life.

Well I specifically didn't say "sterile" but rather "fairly sterile" compared to other water sources.

Edit: As a note to the pedants, of course sterile" is a binary, I used that casually to mean "less microbrial than a lot of the places where our eyes go." ;) <- right eye unfortunately hit the unsterile waters of a chlorinated pool.

Re: The Age of the Superbug Is Here

#35
post #30
post #26

Earlier quoted context omitted.

I don't think that's true at all. I think the issue with contacts (even dailies) is that they can trap pathogens on the surface of the eye and give them a place to breed, allowing an infection to take hold. This could happen within a day while you have your lenses on. I think dailies are somewhat safer, because you're starting each day with a sterile pair. But splashing any non-sterile water onto them is a mistake.

I think that one source of infection is dirty storage pots. That's what NHS Choices says, and they tend to be evidence based (although we can argue about the evidence they use). http://www.nhs.uk/Livewell/Eyehealth/Pages/Contactlenssafety...

That seems plausible. But I was once told that ideally you shouldn't even take a shower in contacts (Not that I always followed that advice). Maybe I just had an over-cautious optometrist.

Re: The Age of the Superbug Is Here

#36
post #8

Earlier quoted context omitted.

If the choice is cheap meat or antibiotics (and yes I know it's not quite that simple) then I'll take antibiotics.

> If the choice is cheap meat or antibiotics Easy to say when you're wealthy, no so much when you consider yourself healthy but poor.

If meat is expensive you can go on to a largely vegetable and plant based diet. Meat is already more expensive than tofu and beans and lentils. And thanks to the Internet, it's now easy to pick up recipes and change ones diet with food from multiple cultures that don't use extensive amounts of meat.

Re: The Age of the Superbug Is Here

#37
post #29

Very naive question: won't bacteria lose their resistance after a while? What if we cycle certain antibiotics on an annual basis? When we reintroduce them, they'll be more powerful. Right?

If you can get the entire human race to match in lockstep with rotating antibiotics in and out, AND the array of antibiotics is large enough, then yes, that's exactly what would happen.

The second part is in the works, constantly. The first part, however, is proving difficult.

Re: The Age of the Superbug Is Here

#40
post #29

Very naive question: won't bacteria lose their resistance after a while? What if we cycle certain antibiotics on an annual basis? When we reintroduce them, they'll be more powerful. Right?

> won't bacteria lose their resistance after a while?

DNA is good at accumulating, and relatively poor at editing out. Some bacteria will lose resistance, just like your ancestors lost the ability to make Vitamin C. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145266/ but you only need one single bacteria to have not lost the ability.

> What if we cycle certain antibiotics on an annual basis?

it helps. We can also stack them, and use multiple attacks at the same time. which also helps. But it just delays the inevitable.

> When we reintroduce them, they'll be more powerful. Right?

the bacteria, yes. because they'll have accumulated defense mechanisms.

Ultimately, I think we win this race, because we can intelligently and actively edit DNA.

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