Live data from Hacker News

Nootropics

gwern.net

31–40 of 404 posts

Re: Nootropics

#31
No mention of methylene blue? :O It's the best one!

Below is a post I wrote on a Ray Peat Facebook group that I think fellow coders and behind-a-desk workers might fight interesting. I've been a serious procrastinator and slacker, and it was a long journey of trial and error in getting diet and lifestyle right. I'm thankful to the amazing work of Dr. Ray Peat, which isn't mentioned enough around Hacker News.

Some comments on maintaining high energy, productivity, creativity and noticeably faster rational thinking (System 2 in the dual process theory) in my day job as a programmer.

◈ Basics first. That is, salt, sugar, calcium, magnesium, A, D, C. If you're lacking any of these you'll have energy problems very quickly. Buy magnesium chloride, add eggshell powder to your mashed potatoes. Get 1g vitamin C pills. Take 5 times as much vitamin A as you take D.

◈ Meditation daily. The main goal of daily meditation for me is to reinforce a stoic mentality, mainly the principle of being indifferent to the external. This is paramount in learning to deal with all kinds of stress. A simple line of thinking that will slowly help you deal with psychological stress better.

◈ Coconut oil-fried eggs. The generally accepted notion around here is that an extremely low fat diet is best for metabolism, i.e., oxidative metabolism is about 15x times more efficient (paraphrasing RP). But saturated fats are extremely good for our brains, because they are used together with cholesterol to generate several hormones (including the wonderful progesterone and pregnenolone). So whatever your brain condition is, if you fry 5 eggs in about 3 tbsp coconut oil, you'll equip your body with the elements it needs to restore its full capacity.

http://www.functionalps.com/blog/2010/12/28/high-cholesterol... http://raypeat.com/articles/articles/cholesterol-longevity.s...

◈ Aspirin and K2. I was for sometime doing 4g aspirin a day, but I noticed that much isn't necessary. Just 1-2g a day along with 1mg K2 is enough.

http://raypeat.com/articles/aging/aspirin-brain-cancer.shtml http://www.functionalps.com/blog/2012/04/22/ray-peat-phd-on-...

◈ Fruits, Lysine, Juices, Niacinamide, Methylene Blue, Coffee. I mention all of these in a single sentence because I use them in sequence, hourly, to keep a long streak of productive hours. I drink some fruit juice (orange, grape, even serotonin-ladden pineapple) with 10gtt 2.3% methylene blue, then eat some fruits (I keep sliced guavas and papayas in the frigde) with 100mg niacinamide and 500mg lysine (serotonin antagonist), followed by 100ml sugared coffee. Rinse. Repeat. I think in total I have been consuming nearly 60gtt 2.3% methylene blue and 1.5L coffee in a stretch of programming work, all with maximum focus, energy, no tiredness (taking very short breaks).

https://raypeatforum.com/community/threads/methylene-blue-mb... https://www.youtube.com/watch?v=GgeZJoir70w https://selfhacked.com/2013/08/25/methylene-blue-the-cheapes...

Main benefit of MB is its effect as a NO and estrogen antagonist, which improves thyroid function and overall energy levels. Stay away from fish oil, polyunsaturated fats are extremely toxic yet you don't see it in the news -- that's because they're everywhere, it's a huge industry and it's not going to go away easily. But PUFAs (polyunsaturated fatty acids) are the #1 source of all kinds of metabolic disorders, including brain fog. Also avoid things that raise serotonin -- serotonin, contrary to decades of misinformation, does not make us happy -- its role in happines is only peripheral. High serotonin in reality is associated with aging, depression and anger. You should aim for high dopamine and low serotonin, in general -- that's why I take a lysine supplement, it competes with serotonin for entry in the brain.

https://pranarupa.wordpress.com/2012/12/25/pufa-because-this... https://pranarupa.wordpress.com/2013/01/31/serotonin-inflamm...

Happy reading.

Re: Nootropics

#32
post #16

Its concerning to see Modafinil on the same list of "defaults" as caffeine and vitamin D. They are on a different scale when it comes to the effect on your brain. That aside, my anecdotal experience of mod is its basically a waste of time. Sure you stay awake longer but we can all easily procrastinate a day away regardless, it wont make you any more focused or any smarter. If you for some reason need to improve your…

If you take a consistent low dose of Adderall at least, there should be nothing wrong with taking it every day and might actually be preferable that way, otherwise you're in for a rollercoaster effect.

The longer you're on though, up to a point at least I imagine, assuming the dose is consistent, you will have a greater withdrawal period that will really suck compared to if you only use them recreationally, which I consider to include situations where you take them only when you need them, such as all nighters; that definitely falls under recreational usage.

Re: Nootropics

#33
post #15

Melatonin has made it possible for me to sleep much more consistently which has been a huge help, since I saw Gwern's post on it a while ago.

You should switch to valerian root if you can. It isn't habit forming in the way that melatonin is. edit: since everybody is asking the same question about habit forming. I am just passing on the information that I got from my doctor. She made this suggestion to me, and it was beneficial to me. Once I had started using melatonin, I would have trouble falling asleep without it. Valarian root didn't cause that issue fo…

I thought that one of the main benefits of melatonin was that it is not habit forming?

Re: Nootropics

#34
post #15

Melatonin has made it possible for me to sleep much more consistently which has been a huge help, since I saw Gwern's post on it a while ago.

You should switch to valerian root if you can. It isn't habit forming in the way that melatonin is. edit: since everybody is asking the same question about habit forming. I am just passing on the information that I got from my doctor. She made this suggestion to me, and it was beneficial to me. Once I had started using melatonin, I would have trouble falling asleep without it. Valarian root didn't cause that issue fo…

Can you elaborate on habit forming? From what I've read it's non-addictive.

Re: Nootropics

#35

Pretty impressive work. I personally use nicotine gum (as does President Obama, a health nut) as I'm allergic to caffeine. I have used melatonin in the past, though given this I will use it more now. The key I find is to only use them when you have already outlined in a detailed way a significant set of tasks that need to be performed or a particularly critical meeting where you already have a very strong background.…

I don't know if I'd call President Obama a health nut; maybe Michelle, but not sure about Barack, unless he quit smoking and switched permanently to the gum.

He exercises constantly and eats food with incredible discipline. He also has the best doctors in the world.

Re: Nootropics

#36
post #18
post #10

Earlier quoted context omitted.

Reddit actually has an active nootropics community with a wiki for beginners: https://www.reddit.com/r/nootropics/wiki/beginners . The standard stuff is L-Theanine + Caffeine. For cognitive enhancement any of the "racetams" are considered proven, and you branch out into untested army drugs when you take modafinil. I've tried each of these and stick with L-Theanine and Caffeine daily. Piracetam had no visible effect o…

In regards to modafinil, it is a schedule IV drug in the US. It's a bit difficult to get and quite expensive. I've done well with adrafinil, which is a prodrug of moda and relatively easy to get.

Modafinil was quite cheap and easy to get in my experience. That was in the middle of the US, nowhere near a big city.

Re: Nootropics

#37

Does anyone else think this shit is totally bat shit crazy? I may be of the minority here but I am definitely not the minority in the real world. If you care about health why not exercise and eat healthy and never take any type of drug for any reason unless you are sick.

Why? There is absolutely nothing inherently wrong with using external catalysts to alter your brain function. We are biological computers and we can alter our programming for better or worse.

Re: Nootropics

#38

Does anyone else think this shit is totally bat shit crazy? I may be of the minority here but I am definitely not the minority in the real world. If you care about health why not exercise and eat healthy and never take any type of drug for any reason unless you are sick.

Most of us take drugs like caffeine and alcohol pretty often.

The person who made this site has been willing to test, meticulously document and analyse his results. He's pretty informed as to the side-effects, so no, I don't think he's "bat shit crazy", he's doing us a service.

Re: Nootropics

#40

Not to generalize but this totally looks like something someone hopped up on amphetamines would write. Get to the point, man.

I think the point was revealed in the first line. "A record of nootropics I have tried, ..."

I don't think it's supposed to be looked at as a one shot article or blog post, but rather a collection of notes / anecdotal evidence / experimentation.

Post reply on HN