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Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

scientificamerican.com

71–80 of 98 posts

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#71
post #63

Earlier quoted context omitted.

At least if they'd kept their findings secret, researchers could independently be researching the same thing. Now independent researchers won't want to touch lugdunin because they'll need to license the patent, however they won't know whether licensing the patent is worthwhile until they do their research. This will prevent further research, not encourage it.

As someone who used to work in drug development, I disagree. Patents don't prevent compounds from being explored in research. If this is anything like other discoveries, companies will start looking at lugdunin very closely. What is it's mechanism of action? Can the structure be optimized? What else could it be used for? Other antibiotics have been patented and that didn't stop companies from doing the research and t…

> What is its mechanism of action?

From this image of the structure (http://cen.acs.org/content/dam/cen/94/31/09431-notw4-Lugduni...) it looks very much like some kind of small pore. That's a total guess, of course, but a cyclic peptide with alternating chirality looks reasonable, although a little small at only 7 residues.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#73
post #66

Earlier quoted context omitted.

> we need more public funding. Otherwise, we have to offer researchers and drug manufacturers an incentive... I'll take researchers for $1,000, Alex. Not a knock to drug manufacturers who are simply acting as they should under the current profit-driven system, but I think we'd be far better off if more of this existential-level stuff (like health) were government functions, or at least government sponsored and not-fo…

If we applied that same logic to space exploration, Space X wouldn't exist.

So, let's instead apply it where I suggested we should.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#74
post #55

Earlier quoted context omitted.

Me too, makes definitely more sense than the other way 'round.

Indeed. It is all about incentives. And in the end, pharmaceutical companies have the incentive to keep people sick so they can keep selling drugs, while the public has the incentive to keep people healthy. So it is actually a no-brainer.

That explains why Gilead produced a cure for hepatitis C.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#75

This is totally misguided. If this develops into a widely used antibiotic it will eventually provoke immunity in its MRSA targets. These same targets will then have free rein in our noses. Not a good deal.

30% of people already have MRSA in their noses. I'm not sure there's a realistic doom and gloom scenario here since if you've got MRSA in your nose, you don't have the lugdunin-producing bacteria anyway.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#76
post #13

This does nothing to solve the real problem. The issue isn't (or wasn't) that we couldn't cure MRSA at all, it was a gradual evolution. In the 1960's we had 5 working drugs that would kill essentially any bacteria. And then we had 4. We discovered new ones, at one point I believe up to 7. But resistance made it go down pretty much by one per decade, but each next one ended faster. And then it hit zero, in 2012 I beli…

We are basically applying selective breeding in order to create the bacteria that will wipe the humanity out, and we are doing a very good job at that..

You realize people died from bacterial infections before antibiotics, right? Bacterial resistance to antibiotics doesn't make the bacteria more likely to kill us than before.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#77
post #13

This does nothing to solve the real problem. The issue isn't (or wasn't) that we couldn't cure MRSA at all, it was a gradual evolution. In the 1960's we had 5 working drugs that would kill essentially any bacteria. And then we had 4. We discovered new ones, at one point I believe up to 7. But resistance made it go down pretty much by one per decade, but each next one ended faster. And then it hit zero, in 2012 I beli…

We are basically applying selective breeding in order to create the bacteria that will wipe the humanity out, and we are doing a very good job at that..

[deleted]

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#78
post #5

Wont using this be long term harmful to our nasal health, as bacteria acquire immunity?

It could happen, but we already have 30% of people with MRSA colonized in their noses. If we develop a new antibiotic that saves thousands or millions of lives, but the MRSA colonization number climbs to, say, 60%, will that be a net gain? I think so, since in general having MRSA colonized is not problematic, and that number is climbing anyway.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#79

Earlier quoted context omitted.

I don't know but it wouldn't make a difference as long as someone else could come along and take out a patent on what they found. This is the sort of thing that requires and international treaty.

I don't see any reason why the researchers couldn't have placed their discovery in the public domain, just as Tim Berners-Lee did with his ideas. Unfortunately many universities (and hence researchers) are under pressure to commercialise their IP, based on the assumption that such behaviour is beneficial to the economy.

Well, which is easier?

1. Get a patent, find a commercial partner and investors who will give you a ton of money to develop it in the hopes of getting a return.

2. Make it public domain, remove any financial incentive to develop it, then try and convince whoever to give you hundreds of millions of dollars to develop it without any hope of financial return?

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#80
post #32
post #30

An interesting point would be that if S. aureus becomes resistant to lugdunin (a matter of a few years maybe), S. lugdunensis might evolve naturally to find a new antibiotic. So a similar study in a few years might lead to a new antibiotic molecule targetting the mutated S. aureus. Is there hope for this or is it nonsense?

I was just thinking something similar - maybe the future for bacterium-specific treatments isn't to try and find a new antibiotic, but rather to pit different nasty bacteria against each other in an endless in-vitro cage match, then analyze the winner to learn their tricks?

The difficulty is creating a suitable environment. There are a lot specifics about a nose that are difficult to duplicate.

Other than that, the idea is perfectly viable.

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