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A Medical Mystery of the Best Kind: Major Diseases Are in Decline

nytimes.com

41–50 of 152 posts

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#41
post #32
post #23

Earlier quoted context omitted.

When smokers give up smoking they start to clear their lungs. They cough up phlegm. many people swallow that, not spit it out. That increases risk of mouth, throat, stomach, bladder, and penis cancer. Tobacco is already pretty harmful. > Chew is full of fiberglass No, it isn't.

Why don't active smokers cough up phlegm?

Many reasons.

Smoking coats the lungs with a layer of tar and heavy, chronic smokers have coated their lungs to such an extent where there is drastically reduced lung area in contact with the environment (and irritants/allergens). The tar acts like a shield in this case and prevents immune response that can lead to constriction in the lungs and phlegm production.

Moreover, active smokers have destroyed the cilia in their lungs (which start to regenerate when one quits smoking) and it's the cilia that do most of the cleaning and phlegm expulsion. When one quits smoking, he goes through weeks or months of coughing and increased phlegm production as the cilia start growing back.

Finally, a lot of active (and ex) smokers do cough up phlegm. The co-factors of phlegm production are simply too many for a definite answer. You also have asthmatics and those who suffer from COPD/emphysema.

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#42
post #34

Earlier quoted context omitted.

cancer is caused by swelling, thus anything that reduces it will reduce cancer incidents.

Cancer is caused by swelling?

The cancers that involve "lumps" are not swelling, but performing angiogenesis [1]. Not sure about the blood cancers because, well, I'm not an expert, but I believe that all cancers involve unrestricted cell division of some kind, at least some of the time as a result of a DNA or RNA error.

I believe swelling is typically caused by individual cells or tissues (or even pockets in the body) building up fluids of one kind or another. Unfortunately cancer can cause this kind of swelling when your liver and/or kidneys shut down. Source: My mom died of breast cancer, and things were not pleasant near the end.

If OP is talking about systemic inflammation...then there may be a link between the two, but it's certainly not the only cause. [2]

[1] https://en.wikipedia.org/wiki/Angiogenesis

[2] https://en.wikipedia.org/wiki/Systemic_inflammation

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#43
post #34

Earlier quoted context omitted.

cancer is caused by swelling, thus anything that reduces it will reduce cancer incidents.

Cancer is caused by swelling?

Perhaps he means inflammation. Inflammation has been linked to certain types of cancers.

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#44
On the other hand, autoimmune diseases have been increasing in prevalence over the last century. While these diseases are rarely immediately fatal, in severe cases they can have a major impact on quality of life. Onset often occurs in early adulthood so the cost of treatment over a lifetime can be extremely high. The usual treatment, immunosuppressive therapy, also has serious risks of its own.

While there has been much progress on finding new treatments, their scope has been limited to new and creative ways of suppressing the immune system. There are a multitude of theories which attempt to explain the causes of autoimmune diseases, but we seem to be quite far from truly understanding them.

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#45
post #28
post #6

Earlier quoted context omitted.

Any idea if that includes Type I, or only Type II?

Type II. Type II is insulin resistance. Which is probably caused by our industrial diet and maybe other factors. The rate is increasing dramatically. Type I is an autoimmune disease. I think it's not increasing. (no idea)

Type 1 diabetes is increasing:

http://diabetes.diabetesjournals.org/content/51/12/3353

The reasons are unknown:

http://www.ncbi.nlm.nih.gov/pubmed/23733895

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#46
post #39
post #10

Earlier quoted context omitted.

I found a chart showing the prevalence of multiple forms of cancer over time: http://i52.tinypic.com/r9euci.jpg .

Weird. Why would lung cancer go the opposite direction as smoking prevalence? I understand the dynamic of "cancer only kills people who outlive every other cause of death", but for the discorrelation to be that strong?

smoking rates was dropping quickly since 1945, during the period lung cancer rates were going up significantly.

death is a bad stat to look at; incidents would be more useful

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#47
post #39
post #10

Earlier quoted context omitted.

I found a chart showing the prevalence of multiple forms of cancer over time: http://i52.tinypic.com/r9euci.jpg .

Weird. Why would lung cancer go the opposite direction as smoking prevalence? I understand the dynamic of "cancer only kills people who outlive every other cause of death", but for the discorrelation to be that strong?

If I were to guess, the results lag behind the prevalence. It takes many years for someone to get cancer. If you were to push back the graph by 20 years it may correlate strongly.

Edit: Also, the U.S. banned asbestos in 1989. That's the turning point of the graph.

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#48

I always wondered if the removal of lead in gasoline could account for a lot of this. Especially the dementia drop.

It is never one thing; your lead assessment is probably a serious contender among other pollutants. Then there is better hygiene via food handlers, stiffer USDA rules, cleaner water, less smoking and second hand smoke, more people exercising too.

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#49
post #28
post #6

Earlier quoted context omitted.

Any idea if that includes Type I, or only Type II?

Type II. Type II is insulin resistance. Which is probably caused by our industrial diet and maybe other factors. The rate is increasing dramatically. Type I is an autoimmune disease. I think it's not increasing. (no idea)

its less caused by diet than lack of mobility. we spend most of our waking day sitting down now. active over weight people with 'bad diets' are healthier than skinny inactive people. but its hard to legislate that, and much easier to pound the shoe on the table about sodas than it is to tell people they need to get up and move

Re: A Medical Mystery of the Best Kind: Major Diseases Are in Decline

#50

Speculation: - People have become more aware of the risk factors, and behave accordingly. Awareness would be connected to prevalence but have a lagged effect. - Deadly diseases cause evolutionary responses. Perhaps a disproportionate number of people with predisposition to these illnesses passed away before having offspring. - Reporting bias? While an illness looms large in the minds of the medical community, doctors…

I don't think you'd see any significant evolutionary responses in the timeframes the article is talking about (<100 years or 4 generations)
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