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Crispr Wins Key Approval to Fight Cancer in Human Trials

bloomberg.com

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Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#81

Post by godbov »

cioc wrote: post #56

If you think stuff like this is cool, and you'd like to be a part of the software engineering effort at Parker Institute for Cancer Immunotherapy, msg me. ccary@parkerici.org We are building out our platform for bioinformatics. Some engineering topics: * Large scale data processing (Cloud & on-prem HPC based) * Bioinformatics / ML algorithms * Data storage & retrieval (File systems & databases)

I've got a background in machine learning (NLP, and a little bit of vision) and electrical engineering, but I know very little about biology. Essentially, all I know is a working knowledge based on what I remember from high school. However, I'm incredibly fascinated by some of these recent developments in making biology more computational! I've started working through some Coursera courses on bioinformatics systems biology, and have been totally engrossed so far!

I noticed that the Parker Institute is a non-profit? I was curious what kind of ramp-up path you offer people like me, with a background in ML, and are excited to learn some more biology if they join the team? Since you're a non-profit, I was wondering if there'd be any interest in helping to curate a bunch of links/resources/etc. so people like me can learn and ramp-up in our spare time? I guess I'm wondering if it's difficult to hire for this role. So maybe other non-profits, e.g. J. Craig Venter Institute may also be interested in helping to curate these resources to help increase supply of possible hires?

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#82

Post by dnautics »

robbiep wrote: post #42
dnautics wrote: post #20

Earlier quoted context omitted.

hey - just want clarification. I thought TKIs like gleevec give an asymptomatic period of years - do you mean by "develop resistance" the initial seed population of cells that are resistant emerge from a (presumably clonal or near-clonal) pool within months? Second: Do you know if clinically, agents like gleevec are primarily used as standalone or in conjunction with more aggressive (and, unfortunately, side-effect l…

Imatinib and other TKIs provide a range of effectiveness, from weeks/months to years. Nothing is forever (although the CD1 Ligands like ipilimumab etc show promise). Mostly, the TKIs spread the Kaplan-Meyer curve out/lengthen it, but because it is still relying on the immune system to kill the cells (mostly) essentially TKIs are providing cellular senescence rather than cellular death. The bcr/abl mutation that imati…

ah... so standard chemo/rad isn't used because the immune response to clear out the senecent bastards will be compromised.

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#83

Post by amelius »

cioc wrote: post #56

If you think stuff like this is cool, and you'd like to be a part of the software engineering effort at Parker Institute for Cancer Immunotherapy, msg me. ccary@parkerici.org We are building out our platform for bioinformatics. Some engineering topics: * Large scale data processing (Cloud & on-prem HPC based) * Bioinformatics / ML algorithms * Data storage & retrieval (File systems & databases)

If this is a non-profit organization, does this mean that the resulting software will become open-source?

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#84

Post by fasteo »

baldfat wrote: post #24

Having lost a sister and a son to cancer I hope for this to work. The issues are tremendous for this technique and I don't have high hopes for its use on cancer. I am still having high hopes on immune system techniques that helps the body to mark cancer cells and attack the cells for most cancers. CRISPR big hope is that it can change the cell to stop reproducing or stop invading other cells. Simply put cancer cells…

So sorry, no father should see his son die.

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#85

Post by whamlastxmas »

baldfat wrote: post #76
davesque wrote: post #59

Earlier quoted context omitted.

Sorry to hear that. Hang in there. I lost my mom to cancer about a year ago.

> Hang in there I have learned through this that A) I depend on God B) I love life and cherish more because of the journey. SO they have made enjoy life more because they were in my life. > I lost my mom to cancer Sorry to hear that. Cancer SUCKS

I'm glad to hear you found some good from such a terrible situation.

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#86

Post by victoriadanahy »

No doubt, CRISPR is the next big thing that will make sense for everyone.

I work for Synthego and we make synthetic RNA for CRISPR/Cas9 Genome Engineering. Our process is fully automated with robots and an architected LAB synthesizer.

We are actively hiring:

* Full Stack Engineers with strong DB and Python skillS * Robotics/Mechanical Engineers with automation experience AND who think outside the box! *Extraordinary Human Beings are welcome too

If you are interested --> email me: victoria.danahy@synthego.com :-)

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#87

Post by cioc »

godbov wrote: post #81
cioc wrote: post #56

If you think stuff like this is cool, and you'd like to be a part of the software engineering effort at Parker Institute for Cancer Immunotherapy, msg me. ccary@parkerici.org We are building out our platform for bioinformatics. Some engineering topics: * Large scale data processing (Cloud & on-prem HPC based) * Bioinformatics / ML algorithms * Data storage & retrieval (File systems & databases)

I've got a background in machine learning (NLP, and a little bit of vision) and electrical engineering, but I know very little about biology. Essentially, all I know is a working knowledge based on what I remember from high school. However, I'm incredibly fascinated by some of these recent developments in making biology more computational! I've started working through some Coursera courses on bioinformatics systems b…

Hey, could you msg me to talk about this. Thanks!

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#88

Post by godbov »

cioc wrote: post #87
godbov wrote: post #81

Earlier quoted context omitted.

I've got a background in machine learning (NLP, and a little bit of vision) and electrical engineering, but I know very little about biology. Essentially, all I know is a working knowledge based on what I remember from high school. However, I'm incredibly fascinated by some of these recent developments in making biology more computational! I've started working through some Coursera courses on bioinformatics systems b…

Hey, could you msg me to talk about this. Thanks!

Cool, I've sent you a follow up email.

Re: Crispr Wins Key Approval to Fight Cancer in Human Trials

#89

Post by Fomite »

reasonattlm wrote: post #73
Fomite wrote: post #66

Earlier quoted context omitted.

Ironically, you skipped "Give it to a lab whose research you want to support."

True. In fairness, that's much harder to do at lower levels of money than either of the options I suggested, despite efforts like labcures.com. You need to know a lot more about the field than you'd need to know in order to give to a non-profit in the space.

True. Unfortunately, there's also a lot of spaces in science where there isn't a clear and direct non-profit necessarily working in the space and funding research.
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