The main problem for me, is that Flow doesn't support Windows (yet?). I've been working solo on a frontend a couple of months now, and the team has just been extended with a new developer (yay). However, he uses Windows, and so all my type annotations are worthless. We're making the switch to TypeScript once 2.0 is released (easier to port with strictNullChecks).
Really wondering: who is developing Node/JS on Windows nowadays? Not that I don't like Windows (I like W10 + the new Ubuntu within efforts a lot), but the ecosystem around Node is so much tailored around Linux. Even with OSX where we have an excellent support, there's still some slight friction when deploying to Ubuntu. Or is Windows 10 a viable alternative for Node devs?
I don't have any problems. I have sometimes found bugs introduced into a library that only affects one platform but not the others. This has happened on things like grunt-plugins rather than more critical libraries. It hasn't caused any drama other than delaying updating a dependency until its fixed.