Cancer therapy by RNA delivery to dendritic cells

Paywall: I read this as an ability to help in immunotherapy which works like a vaccine. I really am interested in what types of cancer this works with the strongest effect. They list soft tumors in Lungs.

The bellow citation seems to show that these are something that could work on all cancer types and is cheap. These are exciting times.

Now it will be another 5 years till we see this even in a trial for children? (Son and sister died of cancer and my daughter's 10 year old friend (same cancer as my sister) is in immunotherapy trial which we are praying for a miracle for her reoccurring brain cancer.

> RNA-LPX vaccines are fast and inexpensive to produce, and virtually any tumour antigen can be encoded by RNA.

Re: Cancer therapy by RNA delivery to dendritic cells

#6

Post by baldfat » Thu, Jun 02, 2016, 1:00 PM UTC

superfx wrote: post #3

Here's the full article for those interested: http://rdcu.be/iFZr

Thank you for the link

Re: Cancer therapy by RNA delivery to dendritic cells

#7

Post by VSerge » Thu, Jun 02, 2016, 1:26 PM UTC

teekert wrote: post #2

This link does work, assuming it is the same article: http://www.nature.com/nature/journal/vaop/ncurrent/full/natu...

thanks

Re: Cancer therapy by RNA delivery to dendritic cells

#8

Post by Aelinsaar » Thu, Jun 02, 2016, 2:23 PM UTC

baldfat wrote: post #5

Paywall: I read this as an ability to help in immunotherapy which works like a vaccine. I really am interested in what types of cancer this works with the strongest effect. They list soft tumors in Lungs. The bellow citation seems to show that these are something that could work on all cancer types and is cheap. These are exciting times. Now it will be another 5 years till we see this even in a trial for children? (S…

It's very exciting, but as these therapies become more successful, we're going to have to tackle the adverse reactions both acute, and chronic. Granted, you're surviving cancer so that's not the primary concern, but it will be a concern.

Re: Cancer therapy by RNA delivery to dendritic cells

#9

Post by reasonattlm » Thu, Jun 02, 2016, 2:26 PM UTC

Paper: http://dx.doi.org/10.1038/nature18300

Company release: http://biontech.de/2016/06/01/nature-publication-describes-f...

Really it is pretty random as to what cancer research and development gets more or less attention from the media and public. Merit has little to do with it. You should assume that any given article like this is representative of many similar ones that passed by without comment.

The most important thing for any approach aspiring to be widespread in the next generation of cancer research is how costly it is to adapt the platform to any specific cancer. The only way to make real inroads in control of cancer is to crush down the cost of addressing different cancers, making it a small project rather than a whole new research initiative each time around.

Re: Cancer therapy by RNA delivery to dendritic cells

#10

Post by baldfat » Thu, Jun 02, 2016, 2:44 PM UTC

Aelinsaar wrote: post #8

baldfat wrote: post #5

Paywall: I read this as an ability to help in immunotherapy which works like a vaccine. I really am interested in what types of cancer this works with the strongest effect. They list soft tumors in Lungs. The bellow citation seems to show that these are something that could work on all cancer types and is cheap. These are exciting times. Now it will be another 5 years till we see this even in a trial for children? (S…

It's very exciting, but as these therapies become more successful, we're going to have to tackle the adverse reactions both acute, and chronic. Granted, you're surviving cancer so that's not the primary concern, but it will be a concern.

Well that is the Number One Reason why they are going immuntheraphy the side effects are minor compared to Chemo and Radiation. This is your own body fighting the cancer.