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Neurons Constantly Alter Their DNA (2015)

hopkinsmedicine.org

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Re: Neurons Constantly Alter Their DNA (2015)

#31
post #5
post #2

The use of "rewrite" is a bit misleading- what's being altered in this mechanism is an epigenetic tag that sits "on top" of one of the standard DNA bases; that an individual's epigenetics are altered as they go through life is well known. But since the underlying cytosine is (as far as we know) irrevocably bound to this tag, it has to be replaced by a different (but identical) cytosine. Its more like going over your…

Actually, it's been a thing for a while that we know the brain has somatic mutations which cause the DNA to differ from cell to cell. While the epigenetic tags are also affected, it goes beyond attaching tags. The brain literally rewrites its own DNA. https://www.genomeweb.com/sequencing-technology/single-neuro...

Better link without paywall and with link to actual article

http://neurosciencenews.com/neuron-lineage-genetics-2792/

Re: Neurons Constantly Alter Their DNA (2015)

#32
Many years ago I attended a talk by Bernard Widrow (discovered/invented a precursor to the backpropagation algorithm; i.e. the least mean squares filter) [1]. He believed that long-term memories are stored in DNA [2]. At the time, I and others thought he was completely wrong.

Maybe it is not such a crazy idea. Code is data, after all (especially if our brains are written in LISP).

[1] https://en.wikipedia.org/wiki/Bernard_Widrow [2] https://web.stanford.edu/class/ee373b/cognitive_memory2.pdf

Re: Neurons Constantly Alter Their DNA (2015)

#33

If this is the case, then we have an intersting problem. Epigenetics change, DNA - due to mutations can differ from cell to cell, people get injected with completely different DNA in the case of organ transplant. New neural pathways are created. Cells in the body are changed constantly. Memories are changed. Things like height, weight, personality traits, name, disorders, spatial location etc. can all be changed as w…

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