Earlier quoted context omitted.
Check this out: http://geneticgenie.org/blog/2013/02/01/think-supporting-met...
Yes, and? The entire website stinks of snake oil. The AJHG paper they cite to is talking about folate and methylation in the context of fetal abnormalities. This is a whole different beast from feeding adults B12 vitamins and hoping for the best.
Well you are supposed to do a blood test for the metabolites that occur in the methylation pathway, to see if the cycle is running correctly. Not sure if that is mentioned on this particular site, but this is what people are doing for example on this ME/CFS forum [1]
> The entire website stinks of snake oil
You could still be right about this (or not), of course. I'd also like to see some clinical trials of this approach.
[1] http://forums.phoenixrising.me/index.php?threads/methylation...